| Title |
Diet-dependent acid load and type 2 diabetes: pooled results from three prospective cohort studies
|
|---|---|
| Published in |
Diabetologia, November 2016
|
| DOI | 10.1007/s00125-016-4153-7 |
| Pubmed ID | |
| Authors |
Jessica C. Kiefte-de Jong, Yanping Li, Mu Chen, Gary C. Curhan, Josiemer Mattei, Vasanti S. Malik, John P. Forman, Oscar H. Franco, Frank B. Hu |
| Abstract |
Studies suggest a potential link between low-grade metabolic acidosis and type 2 diabetes. A western dietary pattern increases daily acid load but the association between diet-dependent acid load and type 2 diabetes is still unclear. This study aimed to assess whether diet-dependent acid load is associated with the risk of type 2 diabetes. We examined the association between energy-adjusted net endogenous acid production (NEAP), potential renal acid load (PRAL) and animal protein-to-potassium ratio (A:P) on incident type 2 diabetes in 67,433 women from the Nurses' Health Study, 84,310 women from the Nurses' Health Study II and 35,743 men from the Health Professionals' Follow-up Study who were free from type 2 diabetes, cardiovascular disease and cancer at baseline. Study-specific HRs were estimated using Cox proportional hazards models with time-varying covariates and were pooled using a random effects meta-analysis. We documented 15,305 cases of type 2 diabetes during 4,025,131 person-years of follow-up. After adjustment for diabetes risk factors, dietary NEAP, PRAL and A:P were positively associated with type 2 diabetes (pooled HR [95% CI] for highest (Q5) vs lowest quintile (Q1): 1.29 [1.22, 1.37], p trend <0.0001; 1.29 [1.22, 1.36], p trend <0.0001 and 1.32 [1.24, 1.40], p trend <0.0001 for NEAP, PRAL and A:P, respectively). These results were not fully explained by other dietary factors including glycaemic load and dietary quality (HR [95% CI] for Q5 vs Q1: 1.21 [1.09, 1.33], p trend <0.0001; 1.19 [1.08, 1.30] and 1.26 [1.17, 1.36], p trend <0.0001 for NEAP, PRAL and A:P, respectively). This study suggests that higher diet-dependent acid load is associated with an increased risk of type 2 diabetes. This association is not fully explained by diabetes risk factors and overall diet quality. |
X Demographics
The data shown below were collected from the profiles of 14 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | 29% |
| United States | 2 | 14% |
| Germany | 1 | 7% |
| Switzerland | 1 | 7% |
| United Arab Emirates | 1 | 7% |
| Unknown | 5 | 36% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 10 | 71% |
| Practitioners (doctors, other healthcare professionals) | 3 | 21% |
| Scientists | 1 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 102 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| Unknown | 101 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 19 | 19% |
| Researcher | 9 | 9% |
| Student > Master | 8 | 8% |
| Student > Ph. D. Student | 7 | 7% |
| Student > Doctoral Student | 7 | 7% |
| Other | 19 | 19% |
| Unknown | 33 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 26 | 25% |
| Nursing and Health Professions | 20 | 20% |
| Unspecified | 7 | 7% |
| Biochemistry, Genetics and Molecular Biology | 4 | 4% |
| Agricultural and Biological Sciences | 4 | 4% |
| Other | 5 | 5% |
| Unknown | 36 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 February 2019.
All research outputs
#3,124,505
of 24,195,945 outputs
Outputs from Diabetologia
#1,519
of 5,226 outputs
Outputs of similar age
#60,713
of 425,698 outputs
Outputs of similar age from Diabetologia
#38
of 73 outputs
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