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SOCS1 gene transfer accelerates the transition to heart failure through the inhibition of the gp130/JAK/STAT pathway

Overview of attention for article published in Cardiovascular Research, August 2012
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Title
SOCS1 gene transfer accelerates the transition to heart failure through the inhibition of the gp130/JAK/STAT pathway
Published in
Cardiovascular Research, August 2012
DOI 10.1093/cvr/cvs261
Pubmed ID
Authors

Antonio Cittadini, Maria Gaia Monti, Guido Iaccarino, Maria Carmina Castiello, Alfonso Baldi, Eduardo Bossone, Salvatore Longobardi, Alberto Maria Marra, Valentina Petrillo, Lavinia Saldamarco, Matthew John During, Luigi Saccà, Gianluigi Condorelli

Abstract

The suppressors of cytokine signalling (SOCS) are identified inhibitors of cytokine and growth factor signalling that act via the Janus kinase (JAK) signal transducers and activators of transcription (STAT) pathways. Aberrant JAK/STAT signalling promotes progression from hypertrophy to heart failure. Little information is available concerning the role of SOCS in the transition from hypertrophy to heart failure. To this aim, we investigated the effects of SOCS1 overexpression obtained by in vivo adeno-associated gene transfer using an aortopulmonary cross-clamping technique in a chronic pressure-overload cardiac rat model.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 39 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 23%
Researcher 7 18%
Professor > Associate Professor 6 15%
Professor 2 5%
Student > Master 2 5%
Other 4 10%
Unknown 9 23%
Readers by discipline Count As %
Medicine and Dentistry 14 36%
Biochemistry, Genetics and Molecular Biology 6 15%
Pharmacology, Toxicology and Pharmaceutical Science 3 8%
Immunology and Microbiology 2 5%
Psychology 2 5%
Other 3 8%
Unknown 9 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 April 2013.
All research outputs
#22,987,510
of 25,630,321 outputs
Outputs from Cardiovascular Research
#51
of 61 outputs
Outputs of similar age
#167,244
of 184,993 outputs
Outputs of similar age from Cardiovascular Research
#8
of 8 outputs
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So far Altmetric has tracked 61 research outputs from this source. They receive a mean Attention Score of 1.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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