| Title |
Oral anti-inflammatory activity of cannabidiol, a non-psychoactive constituent of cannabis, in acute carrageenan-induced inflammation in the rat paw
|
|---|---|
| Published in |
Naunyn-Schmiedeberg's Archives of Pharmacology, February 2004
|
| DOI | 10.1007/s00210-004-0871-3 |
| Pubmed ID | |
| Authors |
Barbara Costa, Mariapia Colleoni, Silvia Conti, Daniela Parolaro, Chiara Franke, Anna Elisa Trovato, Gabriella Giagnoni |
| Abstract |
Cannabidiol, the major non-psychoactive component of marijuana, has various pharmacological actions of clinical interest. It is reportedly effective as an anti-inflammatory and anti-arthritic in murine collagen-induced arthritis. The present study examined the anti-inflammatory and anti-hyperalgesic effects of cannabidiol, administered orally (5-40 mg/kg) once a day for 3 days after the onset of acute inflammation induced by intraplantar injection of 0.1 ml carrageenan (1% w/v in saline) in the rat. At the end of the treatment prostaglandin E2 (PGE2) was assayed in the plasma, and cyclooxygenase (COX) activity, production of nitric oxide (NO; nitrite/nitrate content), and of other oxygen-derived free radicals (malondialdehyde) in inflamed paw tissues. All these markers were significantly increased following carrageenan. Thermal hyperalgesia, induced by carrageenan and assessed by the plantar test, lasted 7 h. Cannabidiol had a time- and dose-dependent anti-hyperalgesic effect after a single injection. Edema following carrageenan peaked at 3 h and lasted 72 h; a single dose of cannabidiol reduced edema in a dose-dependent fashion and subsequent daily doses caused further time- and dose-related reductions. There were decreases in PGE2 plasma levels, tissue COX activity, production of oxygen-derived free radicals, and NO after three doses of cannabidiol. The effect on NO seemed to depend on a lower expression of the endothelial isoform of NO synthase. In conclusion, oral cannabidiol has a beneficial action on two symptoms of established inflammation: edema and hyperalgesia. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 220 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| United Kingdom | 1 | <1% |
| India | 1 | <1% |
| China | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 214 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 34 | 15% |
| Student > Bachelor | 30 | 14% |
| Student > Master | 26 | 12% |
| Researcher | 21 | 10% |
| Other | 15 | 7% |
| Other | 31 | 14% |
| Unknown | 63 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 30 | 14% |
| Agricultural and Biological Sciences | 27 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 20 | 9% |
| Biochemistry, Genetics and Molecular Biology | 15 | 7% |
| Neuroscience | 13 | 6% |
| Other | 40 | 18% |
| Unknown | 75 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 February 2018.
All research outputs
#7,205,554
of 25,374,917 outputs
Outputs from Naunyn-Schmiedeberg's Archives of Pharmacology
#391
of 1,892 outputs
Outputs of similar age
#29,829
of 144,511 outputs
Outputs of similar age from Naunyn-Schmiedeberg's Archives of Pharmacology
#34
of 38 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 1,892 research outputs from this source. They receive a mean Attention Score of 4.2. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 144,511 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.