Title |
Cancer Risks for BRCA1 and BRCA2 Mutation Carriers: Results From Prospective Analysis of EMBRACE
|
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Published in |
JNCI: Journal of the National Cancer Institute, April 2013
|
DOI | 10.1093/jnci/djt095 |
Pubmed ID | |
Authors |
Nasim Mavaddat, Susan Peock, Debra Frost, Steve Ellis, Radka Platte, Elena Fineberg, D. Gareth Evans, Louise Izatt, Rosalind A. Eeles, Julian Adlard, Rosemarie Davidson, Diana Eccles, Trevor Cole, Jackie Cook, Carole Brewer, Marc Tischkowitz, Fiona Douglas, Shirley Hodgson, Lisa Walker, Mary E. Porteous, Patrick J. Morrison, Lucy E. Side, M. John Kennedy, Catherine Houghton, Alan Donaldson, Mark T. Rogers, Huw Dorkins, Zosia Miedzybrodzka, Helen Gregory, Jacqueline Eason, Julian Barwell, Emma McCann, Alex Murray, Antonis C. Antoniou, Douglas F. Easton |
Abstract |
Reliable estimates of cancer risk are critical for guiding management of BRCA1 and BRCA2 mutation carriers. The aims of this study were to derive penetrance estimates for breast cancer, ovarian cancer, and contralateral breast cancer in a prospective series of mutation carriers and to assess how these risks are modified by common breast cancer susceptibility alleles. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 25% |
France | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Scientists | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | <1% |
Uruguay | 1 | <1% |
Brazil | 1 | <1% |
Ireland | 1 | <1% |
Canada | 1 | <1% |
United Kingdom | 1 | <1% |
Greece | 1 | <1% |
Japan | 1 | <1% |
Unknown | 620 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 98 | 16% |
Researcher | 87 | 14% |
Student > Master | 77 | 12% |
Student > Bachelor | 60 | 10% |
Other | 48 | 8% |
Other | 104 | 17% |
Unknown | 156 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 188 | 30% |
Biochemistry, Genetics and Molecular Biology | 105 | 17% |
Agricultural and Biological Sciences | 83 | 13% |
Nursing and Health Professions | 20 | 3% |
Psychology | 9 | 1% |
Other | 43 | 7% |
Unknown | 182 | 29% |