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Mendeley readers
Attention Score in Context
| Title |
Biodegradable Magnetic Silica@Iron Oxide Nanovectors with Ultra-Large Mesopores for High Protein Loading, Magnetothermal Release, and Delivery
|
|---|---|
| Published in |
Journal of Controlled Release, November 2016
|
| DOI | 10.1016/j.jconrel.2016.11.032 |
| Pubmed ID | |
| Authors |
Haneen Omar, Jonas G. Croissant, Kholod Alamoudi, Shahad Alsaiari, Ibrahim Alradwan, Majed A. Majrashi, Dalaver H. Anjum, Patricia Martins, Ria Laamarti, Jorg Eppinger, Basem Moosa, Abdulaziz Almalik, Niveen M. Khashab |
| Abstract |
The delivery of large cargos of diameter above 15nm for biomedical applications has proved challenging since it requires biocompatible, stably-loaded, and biodegradable nanomaterials. In this study, we describe the design of biodegradable silica-iron oxide hybrid nanovectors with large mesopores for large protein delivery in cancer cells. The mesopores of the nanomaterials spanned from 20 to 60nm in diameter and post-functionalization allowed the electrostatic immobilization of large proteins (e.g. mTFP-Ferritin, ~534kDa). Half of the content of the nanovectors was based with iron oxide nanophases which allowed the rapid biodegradation of the carrier in fetal bovine serum and a magnetic responsiveness. The nanovectors released large protein cargos in aqueous solution under acidic pH or magnetic stimuli. The delivery of large proteins was then autonomously achieved in cancer cells via the silica-iron oxide nanovectors, which is thus a promising for biomedical applications. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Saudi Arabia | 1 | 1% |
| Unknown | 77 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 18% |
| Student > Master | 14 | 18% |
| Student > Ph. D. Student | 12 | 15% |
| Student > Doctoral Student | 7 | 9% |
| Student > Bachelor | 6 | 8% |
| Other | 10 | 13% |
| Unknown | 15 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 18 | 23% |
| Biochemistry, Genetics and Molecular Biology | 11 | 14% |
| Materials Science | 8 | 10% |
| Agricultural and Biological Sciences | 4 | 5% |
| Chemical Engineering | 3 | 4% |
| Other | 9 | 12% |
| Unknown | 25 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 December 2016.
All research outputs
#22,758,309
of 25,373,627 outputs
Outputs from Journal of Controlled Release
#8,647
of 9,727 outputs
Outputs of similar age
#356,953
of 416,861 outputs
Outputs of similar age from Journal of Controlled Release
#84
of 109 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 9,727 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 416,861 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 109 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.