Title |
PIK3CA and PTEN Gene and Exon Mutation-Specific Clinicopathologic and Molecular Associations in Colorectal Cancer
|
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Published in |
Clinical Cancer Research, June 2013
|
DOI | 10.1158/1078-0432.ccr-12-3614 |
Pubmed ID | |
Authors |
Fiona L. Day, Robert N. Jorissen, Lara Lipton, Dmitri Mouradov, Anuratha Sakthianandeswaren, Michael Christie, Shan Li, Cary Tsui, Jeannie Tie, Jayesh Desai, Zheng-Zhou Xu, Peter Molloy, Vicki Whitehall, Barbara A. Leggett, Ian T. Jones, Stephen McLaughlin, Robyn L. Ward, Nicholas J. Hawkins, Andrew R. Ruszkiewicz, James Moore, Dana Busam, Qi Zhao, Robert L. Strausberg, Peter Gibbs, Oliver M. Sieber |
Abstract |
PIK3CA and PTEN mutations are prevalent in colorectal cancer and potential markers of response to mitogen-activated protein/extracellular signal-regulated kinase inhibitors and anti-EGF receptor antibody therapy. Relationships between phosphoinositide 3-kinase (PI3K) pathway mutation, clinicopathologic characteristics, molecular features, and prognosis remain controversial. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Italy | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | <1% |
Unknown | 118 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 31 | 26% |
Student > Master | 18 | 15% |
Student > Ph. D. Student | 15 | 13% |
Student > Bachelor | 11 | 9% |
Other | 10 | 8% |
Other | 14 | 12% |
Unknown | 20 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 49 | 41% |
Biochemistry, Genetics and Molecular Biology | 24 | 20% |
Agricultural and Biological Sciences | 16 | 13% |
Arts and Humanities | 2 | 2% |
Engineering | 2 | 2% |
Other | 6 | 5% |
Unknown | 20 | 17% |