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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Weight Loss after Gastric Bypass Is Associated with a Variant at 15q26.1
|
|---|---|
| Published in |
American Journal of Human Genetics, May 2013
|
| DOI | 10.1016/j.ajhg.2013.04.009 |
| Pubmed ID | |
| Authors |
Ida J. Hatoum, Danielle M. Greenawalt, Chris Cotsapas, Mark J. Daly, Marc L. Reitman, Lee M. Kaplan |
| Abstract |
The amount of weight loss attained after Roux-en-Y gastric bypass (RYGB) surgery follows a wide and normal distribution, and recent evidence indicates that this weight loss is due to physiological, rather than mechanical, mechanisms. To identify potential genetic factors associated with weight loss after RYGB, we performed a genome-wide association study (GWAS) of 693 individuals undergoing RYGB and then replicated this analysis in an independent population of 327 individuals undergoing RYGB. We found that a 15q26.1 locus near ST8SIA2 and SLCO3A1 was significantly associated with weight loss after RYGB. Expression of ST8SIA2 in omental fat of these individuals at baseline was significantly associated with weight loss after RYGB. Gene expression analysis in RYGB and weight-matched, sham-operated (WMS) mice revealed that expression of St8sia2 and Slco3a1 was significantly altered in metabolically active tissues in RYGB-treated compared to WMS mice. These findings provide strong evidence for specific genetic influences on weight loss after RYGB and underscore the biological nature of the response to RYGB. |
X Demographics
The data shown below were collected from the profiles of 19 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 21% |
| Spain | 2 | 11% |
| Saudi Arabia | 1 | 5% |
| United Kingdom | 1 | 5% |
| Estonia | 1 | 5% |
| Unknown | 10 | 53% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 13 | 68% |
| Scientists | 3 | 16% |
| Practitioners (doctors, other healthcare professionals) | 2 | 11% |
| Science communicators (journalists, bloggers, editors) | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Hong Kong | 1 | 1% |
| United States | 1 | 1% |
| Portugal | 1 | 1% |
| Ukraine | 1 | 1% |
| Unknown | 71 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 20 | 27% |
| Student > Ph. D. Student | 13 | 17% |
| Student > Master | 7 | 9% |
| Professor | 6 | 8% |
| Student > Bachelor | 6 | 8% |
| Other | 15 | 20% |
| Unknown | 8 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 21 | 28% |
| Medicine and Dentistry | 16 | 21% |
| Biochemistry, Genetics and Molecular Biology | 14 | 19% |
| Nursing and Health Professions | 2 | 3% |
| Social Sciences | 2 | 3% |
| Other | 5 | 7% |
| Unknown | 15 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 48. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 September 2022.
All research outputs
#883,396
of 25,626,416 outputs
Outputs from American Journal of Human Genetics
#463
of 5,906 outputs
Outputs of similar age
#6,351
of 204,924 outputs
Outputs of similar age from American Journal of Human Genetics
#3
of 62 outputs
Altmetric has tracked 25,626,416 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,906 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.4. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 204,924 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 62 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.