| Title |
The role of reactive oxygen species in apoptosis of the diabetic kidney
|
|---|---|
| Published in |
Apoptosis, May 2009
|
| DOI | 10.1007/s10495-009-0359-1 |
| Pubmed ID | |
| Authors |
F. A. D. T. G. Wagener, D. Dekker, J. H. Berden, A. Scharstuhl, J. van der Vlag |
| Abstract |
Increased levels of reactive oxygen species (ROS) by hyperglycemia can induce apoptosis of renal cells and diabetic nephropathy. The redox balance in the renal cell seems, therefore, of the utmost importance. ROS-mediated apoptosis may be further aggravated by an inadequate cytoprotective response against ROS. When there are insufficient cytoprotective and ROS scavenging molecules, ROS lead to considerable cellular damage and to a point of no return in apoptosis. Induction of cytoprotective proteins may prevent or attenuate apoptosis, renal cell injury, and finally diabetic nephropathy. Here, we discuss some mechanisms of apoptosis and several strategies that have been probed to ameliorate, or to prevent apoptosis in the diabetic kidney. |
Mendeley readers
The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| China | 1 | 1% |
| Germany | 1 | 1% |
| Unknown | 71 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 22% |
| Researcher | 12 | 16% |
| Student > Master | 12 | 16% |
| Student > Bachelor | 8 | 11% |
| Professor | 3 | 4% |
| Other | 8 | 11% |
| Unknown | 14 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 16 | 22% |
| Biochemistry, Genetics and Molecular Biology | 14 | 19% |
| Medicine and Dentistry | 12 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 7% |
| Neuroscience | 2 | 3% |
| Other | 8 | 11% |
| Unknown | 16 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 July 2013.
All research outputs
#15,270,698
of 22,708,120 outputs
Outputs from Apoptosis
#468
of 802 outputs
Outputs of similar age
#85,331
of 101,009 outputs
Outputs of similar age from Apoptosis
#6
of 6 outputs
Altmetric has tracked 22,708,120 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 802 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
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We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one.