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Mendeley readers
Attention Score in Context
| Title |
The Transcriptional Coactivator Querkopf Controls Adult Neurogenesis
|
|---|---|
| Published in |
Journal of Neuroscience, November 2006
|
| DOI | 10.1523/jneurosci.2247-06.2006 |
| Pubmed ID | |
| Authors |
Tobias D. Merson, Mathew P. Dixon, Caitlin Collin, Rodney L. Rietze, Perry F. Bartlett, Tim Thomas, Anne K. Voss |
| Abstract |
The adult mammalian brain maintains populations of neural stem cells within discrete proliferative zones. Understanding of the molecular mechanisms regulating adult neural stem cell function is limited. Here, we show that MYST family histone acetyltransferase Querkopf (Qkf, Myst4, Morf)-deficient mice have cumulative defects in adult neurogenesis in vivo, resulting in declining numbers of olfactory bulb interneurons, a population of neurons produced in large numbers during adulthood. Qkf-deficient mice have fewer neural stem cells and fewer migrating neuroblasts in the rostral migratory stream. Qkf gene expression is strong in the neurogenic subventricular zone. A population enriched in multipotent cells can be isolated from this region on the basis of Qkf gene expression. Neural stem cells/progenitor cells isolated from Qkf mutant mice exhibited a reduced self-renewal capacity and a reduced ability to produce differentiated neurons. Together, our data show that Qkf is essential for normal adult neurogenesis. |
Mendeley readers
The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Germany | 1 | 1% |
| Portugal | 1 | 1% |
| Spain | 1 | 1% |
| Switzerland | 1 | 1% |
| Unknown | 87 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 27% |
| Researcher | 25 | 27% |
| Student > Bachelor | 8 | 9% |
| Student > Master | 7 | 8% |
| Student > Doctoral Student | 5 | 5% |
| Other | 10 | 11% |
| Unknown | 13 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 38 | 41% |
| Biochemistry, Genetics and Molecular Biology | 17 | 18% |
| Neuroscience | 15 | 16% |
| Engineering | 2 | 2% |
| Nursing and Health Professions | 1 | 1% |
| Other | 4 | 4% |
| Unknown | 16 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 November 2006.
All research outputs
#5,718,233
of 22,708,120 outputs
Outputs from Journal of Neuroscience
#9,256
of 23,146 outputs
Outputs of similar age
#19,880
of 69,237 outputs
Outputs of similar age from Journal of Neuroscience
#55
of 195 outputs
Altmetric has tracked 22,708,120 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 23,146 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.3. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 69,237 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 195 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.