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Mendeley readers
Attention Score in Context
| Title |
Presynaptic CLC-3 determines quantal size of inhibitory transmission in the hippocampus
|
|---|---|
| Published in |
Nature Neuroscience, March 2011
|
| DOI | 10.1038/nn.2775 |
| Pubmed ID | |
| Authors |
Vladimir Riazanski, Ludmila V Deriy, Pavel D Shevchenko, Brandy Le, Erwin A Gomez, Deborah J Nelson |
| Abstract |
The absence of the chloride channel CLC-3 in Clcn3(-/-) mice results in hippocampal degeneration with a distinct temporal-spatial sequence that resembles neuronal loss in temporal lobe epilepsy. We examined how the loss of CLC-3 might affect GABAergic synaptic transmission in the hippocampus. An electrophysiological study of synaptic function in hippocampal slices taken from Clcn3(-/-) mice before the onset of neurodegeneration revealed a substantial decrease in the amplitude and frequency of miniature inhibitory postsynaptic currents compared with those in wild-type slices. We found that CLC-3 colocalized with the vesicular GABA transporter VGAT in the CA1 region of the hippocampus. Acidification of inhibitory synaptic vesicles induced by Cl(-) showed a marked dependence on CLC-3 expression. The decrease in inhibitory transmission in Clcn3(-/-) mice suggests that the neurotransmitter loading of synaptic vesicles was reduced, which we attribute to defective vesicular acidification. Our observations extend the role of Cl(-) in inhibitory transmission from that of a postsynaptic permeant species to a presynaptic regulatory element. |
Mendeley readers
The data shown below were compiled from readership statistics for 112 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 4% |
| Germany | 2 | 2% |
| Portugal | 1 | <1% |
| Czechia | 1 | <1% |
| France | 1 | <1% |
| Japan | 1 | <1% |
| United Kingdom | 1 | <1% |
| Unknown | 100 | 89% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 37 | 33% |
| Student > Ph. D. Student | 24 | 21% |
| Professor > Associate Professor | 11 | 10% |
| Student > Master | 9 | 8% |
| Professor | 8 | 7% |
| Other | 15 | 13% |
| Unknown | 8 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 53 | 47% |
| Neuroscience | 28 | 25% |
| Medicine and Dentistry | 11 | 10% |
| Biochemistry, Genetics and Molecular Biology | 6 | 5% |
| Engineering | 2 | 2% |
| Other | 2 | 2% |
| Unknown | 10 | 9% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 June 2023.
All research outputs
#2,570,354
of 22,708,120 outputs
Outputs from Nature Neuroscience
#2,595
of 5,210 outputs
Outputs of similar age
#11,780
of 108,736 outputs
Outputs of similar age from Nature Neuroscience
#19
of 53 outputs
Altmetric has tracked 22,708,120 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,210 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 53.0. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 108,736 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 53 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.