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Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease

Overview of attention for article published in Nature Genetics, February 2009
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

blogs
1 blog

Citations

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417 Dimensions

Readers on

mendeley
212 Mendeley
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2 CiteULike
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Title
Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease
Published in
Nature Genetics, February 2009
DOI 10.1038/ng.314
Pubmed ID
Authors

David-Alexandre Trégouët, Inke R König, Jeanette Erdmann, Alexandru Munteanu, Peter S Braund, Alistair S Hall, Anika Großhennig, Patrick Linsel-Nitschke, Claire Perret, Maylis DeSuremain, Thomas Meitinger, Ben J Wright, Michael Preuss, Anthony J Balmforth, Stephen G Ball, Christa Meisinger, Cécile Germain, Alun Evans, Dominique Arveiler, Gérald Luc, Jean-Bernard Ruidavets, Caroline Morrison, Pim van der Harst, Stefan Schreiber, Katharina Neureuther, Arne Schäfer, Peter Bugert, Nour E El Mokhtari, Jürgen Schrezenmeir, Klaus Stark, Diana Rubin, H-Erich Wichmann, Christian Hengstenberg, Willem Ouwehand, Andreas Ziegler, Laurence Tiret, John R Thompson, Francois Cambien, Heribert Schunkert, Nilesh J Samani

Abstract

We identify the SLC22A3-LPAL2-LPA gene cluster as a strong susceptibility locus for coronary artery disease (CAD) through a genome-wide haplotype association (GWHA) study. This locus was not identified from previous genome-wide association (GWA) studies focused on univariate analyses of SNPs. The proposed approach may have wide utility for analyzing GWA data for other complex traits.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 212 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 2%
France 2 <1%
Canada 2 <1%
Netherlands 1 <1%
Italy 1 <1%
Germany 1 <1%
Portugal 1 <1%
United Kingdom 1 <1%
Sweden 1 <1%
Other 5 2%
Unknown 193 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 57 27%
Student > Ph. D. Student 41 19%
Professor > Associate Professor 19 9%
Student > Master 18 8%
Professor 16 8%
Other 40 19%
Unknown 21 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 90 42%
Medicine and Dentistry 45 21%
Biochemistry, Genetics and Molecular Biology 29 14%
Computer Science 6 3%
Mathematics 5 2%
Other 14 7%
Unknown 23 11%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 February 2009.
All research outputs
#3,907,044
of 25,837,817 outputs
Outputs from Nature Genetics
#3,939
of 7,639 outputs
Outputs of similar age
#19,004
of 190,226 outputs
Outputs of similar age from Nature Genetics
#42
of 64 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,639 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.7. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 190,226 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 64 others from the same source and published within six weeks on either side of this one. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.