| Title |
Digestive Enzyme Supplementation for Autism Spectrum Disorders: A Double-Blind Randomized Controlled Trial
|
|---|---|
| Published in |
Journal of Autism and Developmental Disorders, March 2010
|
| DOI | 10.1007/s10803-010-0974-2 |
| Pubmed ID | |
| Authors |
Sujeeva A. Munasinghe, Carolyn Oliff, Judith Finn, John A. Wray |
| Abstract |
To examine the effects of a digestive enzyme supplement in improving expressive language, behaviour and other symptoms in children with Autism Spectrum Disorder. Randomized, double-blind placebo-controlled trial using crossover design over 6 months for 43 children, aged 3-8 years. Outcome measurement tools included monthly Global Behaviour Rating Scales, Additional Rating Scales of other symptoms by parents and therapists, and monthly completion of the Rescorla Language Development Survey. Compared with placebo, treatment with enzyme was not associated with clinically significant improvement in behaviour, food variety, gastrointestinal symptoms, sleep quality, engagement with therapist, or the Language Development Survey Vocabulary or Sentence Complexity Scores. A small statistically significant improvement on enzyme therapy was seen for the food variety scores. No clinically significant effect improvement of autism symptoms with enzyme use was shown with this trial, however, possible effects on improvement in food variety warrants further detailed investigation. |
Mendeley readers
The data shown below were compiled from readership statistics for 149 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Denmark | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 147 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 24 | 16% |
| Student > Ph. D. Student | 20 | 13% |
| Student > Bachelor | 19 | 13% |
| Researcher | 17 | 11% |
| Professor > Associate Professor | 7 | 5% |
| Other | 24 | 16% |
| Unknown | 38 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 29 | 19% |
| Medicine and Dentistry | 26 | 17% |
| Nursing and Health Professions | 14 | 9% |
| Agricultural and Biological Sciences | 10 | 7% |
| Social Sciences | 9 | 6% |
| Other | 16 | 11% |
| Unknown | 45 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 36. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 January 2023.
All research outputs
#1,146,570
of 25,769,258 outputs
Outputs from Journal of Autism and Developmental Disorders
#402
of 5,454 outputs
Outputs of similar age
#3,591
of 103,743 outputs
Outputs of similar age from Journal of Autism and Developmental Disorders
#4
of 39 outputs
Altmetric has tracked 25,769,258 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,454 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.5. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 103,743 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.