Title |
How regulatory T cells work
|
---|---|
Published in |
Nature Reviews Immunology, July 2008
|
DOI | 10.1038/nri2343 |
Pubmed ID | |
Authors |
Dario A. A. Vignali, Lauren W. Collison, Creg J. Workman |
Abstract |
Regulatory T (T(Reg)) cells are essential for maintaining peripheral tolerance, preventing autoimmune diseases and limiting chronic inflammatory diseases. However, they also limit beneficial responses by suppressing sterilizing immunity and limiting antitumour immunity. Given that T(Reg) cells can have both beneficial and deleterious effects, there is considerable interest in determining their mechanisms of action. In this Review, we describe the basic mechanisms used by T(Reg) cells to mediate suppression and discuss whether one or many of these mechanisms are likely to be crucial for T(Reg)-cell function. In addition, we propose the hypothesis that effector T cells may not be 'innocent' parties in this suppressive process and might in fact potentiate T(Reg)-cell function. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 18% |
Mexico | 1 | 9% |
Unknown | 8 | 73% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 9 | 82% |
Practitioners (doctors, other healthcare professionals) | 2 | 18% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
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United Kingdom | 12 | <1% |
Brazil | 11 | <1% |
Germany | 8 | <1% |
Japan | 5 | <1% |
Netherlands | 5 | <1% |
France | 4 | <1% |
Belgium | 4 | <1% |
Mexico | 4 | <1% |
Other | 39 | 1% |
Unknown | 2758 | 96% |
Demographic breakdown
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---|---|---|
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Researcher | 419 | 15% |
Student > Bachelor | 370 | 13% |
Student > Master | 366 | 13% |
Student > Doctoral Student | 171 | 6% |
Other | 378 | 13% |
Unknown | 561 | 20% |
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Pharmacology, Toxicology and Pharmaceutical Science | 55 | 2% |
Other | 205 | 7% |
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