| Title |
Impact of mammographic screening on the detection of good and poor prognosis breast cancers
|
|---|---|
| Published in |
Breast Cancer Research and Treatment, September 2011
|
| DOI | 10.1007/s10549-011-1748-z |
| Pubmed ID | |
| Authors |
Laura J. Esserman, Yiwey Shieh, Emiel J. T. Rutgers, Michael Knauer, Valesca P. Retèl, Stella Mook, Annuska M. Glas, Dan H. Moore, Sabine Linn, Flora E. van Leeuwen, Laura J. van ’t Veer |
| Abstract |
We sought to compare the molecular signature of node negative cancers from two cohorts 15 years apart, to determine if there is molecular evidence of increase in low and ultralow risk cancers over time. We studied the impact of age, time period of diagnosis, and mammographic screening on biology of tumors where The Netherlands Cancer Institute 70-gene prognosis signature was generated as part of 2 validation series, one retrospective (1984-1992), Cohort 1, and one prospective (2004-2006), Cohort 2. A total of 866 patients were analyzed. Regardless of time period of diagnosis, the proportion of T1, grade 1, hormone receptor positive (HR) tumors, and good prognosis by 70-gene signature significantly increases as age increases (P < 0.01). In women aged 49-60, the time period of diagnosis significantly affects the proportion of cancers that were NKI 70-gene low risk: 40.6% (67/165) compared with 58% (119/205) for Cohorts 1 and 2, respectively. This is in contrast to the absence of a significant change for women under age 40, where 25% (17/68) and 30% (17/56) were low risk in Cohorts 1 and 2, respectively. In women aged 49-60, using an ultralow risk threshold of the 70-gene signature, 10% of tumors in Cohort 1 were ultralow risk compared with 30% for women with screen-detected cancers in Cohort 2. Older age and method of detection (screening) are associated with a higher likelihood of a biologically low risk tumor. In women over age 50, biologically low risk tumors are frequent and tools that classify risk may minimize overtreatment. |
Mendeley readers
The data shown below were compiled from readership statistics for 130 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Greece | 1 | <1% |
| Denmark | 1 | <1% |
| France | 1 | <1% |
| Unknown | 127 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 21 | 16% |
| Other | 15 | 12% |
| Student > Bachelor | 13 | 10% |
| Student > Ph. D. Student | 11 | 8% |
| Student > Master | 11 | 8% |
| Other | 27 | 21% |
| Unknown | 32 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 70 | 54% |
| Biochemistry, Genetics and Molecular Biology | 6 | 5% |
| Nursing and Health Professions | 4 | 3% |
| Agricultural and Biological Sciences | 4 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | <1% |
| Other | 7 | 5% |
| Unknown | 38 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 June 2021.
All research outputs
#1,529,880
of 22,709,015 outputs
Outputs from Breast Cancer Research and Treatment
#196
of 4,619 outputs
Outputs of similar age
#7,304
of 125,203 outputs
Outputs of similar age from Breast Cancer Research and Treatment
#3
of 47 outputs
Altmetric has tracked 22,709,015 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,619 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 125,203 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 47 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.