| Title |
Phenotypic and measurement influences on heritability estimates in childhood ADHD
|
|---|---|
| Published in |
European Child & Adolescent Psychiatry, March 2010
|
| DOI | 10.1007/s00787-010-0097-5 |
| Pubmed ID | |
| Authors |
Christine M. Freitag, Luis A. Rohde, Thomas Lempp, Marcel Romanos |
| Abstract |
Twin studies described a strongly heritable component of attention-deficit/hyperactivity disorder (ADHD) in children and adolescents. However, findings varied considerably between studies. In addition, ADHD presents with a high rate of comorbid disorders and associated psychopathology. Therefore, this literature review reports findings from population-based twin studies regarding the influence of subtypes, assessment instruments, rater effects, sex differences, and comorbidity rates on ADHD heritability estimates. In addition, genetic effects on the persistence of ADHD are discussed. By reviewing relevant factors influencing heritability estimates more homogeneous subtypes relevant for molecular genetic studies can be elicited. A systematic search of population-based twin studies in ADHD was performed, using the databases PubMed and PsycInfo. Results of family studies were added in case insufficient or contradictory findings were obtained in twin studies. Heritability estimates were strongly influenced by rater effects and assessment instruments. Inattentive and hyperactive-impulsive symptoms were likely influenced by common as well as specific genetic risk factors. Besides persistent ADHD, ADHD accompanied by symptoms of conduct or antisocial personality disorder might be another strongly genetically determined subtype, however, family environmental risk factors have also been established for this pattern of comorbidity. |
Mendeley readers
The data shown below were compiled from readership statistics for 181 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | 1% |
| United Kingdom | 2 | 1% |
| Brazil | 2 | 1% |
| United States | 2 | 1% |
| Spain | 1 | <1% |
| Hong Kong | 1 | <1% |
| Unknown | 171 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 36 | 20% |
| Student > Ph. D. Student | 30 | 17% |
| Researcher | 24 | 13% |
| Student > Bachelor | 17 | 9% |
| Student > Doctoral Student | 14 | 8% |
| Other | 25 | 14% |
| Unknown | 35 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 72 | 40% |
| Medicine and Dentistry | 19 | 10% |
| Agricultural and Biological Sciences | 9 | 5% |
| Neuroscience | 9 | 5% |
| Social Sciences | 7 | 4% |
| Other | 24 | 13% |
| Unknown | 41 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 February 2012.
All research outputs
#4,446,706
of 22,709,015 outputs
Outputs from European Child & Adolescent Psychiatry
#458
of 1,636 outputs
Outputs of similar age
#19,096
of 93,243 outputs
Outputs of similar age from European Child & Adolescent Psychiatry
#2
of 7 outputs
Altmetric has tracked 22,709,015 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,636 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one has gotten more attention than average, scoring higher than 72% of its peers.
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We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.