| Title |
Clinical application of circulating tumor cells in breast cancer: overview of the current interventional trials
|
|---|---|
| Published in |
Cancer and Metastasis Reviews, November 2012
|
| DOI | 10.1007/s10555-012-9398-0 |
| Pubmed ID | |
| Authors |
François-Clément Bidard, Tanja Fehm, Michail Ignatiadis, Jeffrey B. Smerage, Catherine Alix-Panabières, Wolfgang Janni, Carlo Messina, Costanza Paoletti, Volkmar Müller, Daniel F. Hayes, Martine Piccart, Jean-Yves Pierga |
| Abstract |
In 2004, circulating tumor cells (CTC) enumeration by the CellSearch® technique at baseline and during treatment was reported to be associated with prognosis in metastatic breast cancer patients. In 2008, the first evidence of the impact of CTC detection by this technique on survival of cM0(i+) patients were reported. These findings were confirmed by other non-interventional studies, whereas CTC were also investigated as a surrogate for tumor biology, mainly for HER2 expression/amplification. The aim of this report is to present the current prospective large interventional studies that have been specifically designed to demonstrate that CTC enumeration/characterization may improve the management of breast cancer patients: STIC CTC METABREAST (France) and Endocrine Therapy Index (USA) assess the CTC-guided hormone therapy vs chemotherapy decision in M1 patients; SWOG0500 (USA) and CirCe01 (France) assess the CTC count changes during treatment in metastatic patients; DETECT III (M1 patients, Germany) and Treat CTC (cM0(i+) patients, European Organization for Research and Treatment of Cancer/Breast International Group) assess the use of anti-HER2 treatments in HER2-negative breast cancer patients selected on the basis of CTC detection/characterization. These trials have different designs in various patient populations but are expected to be the pivotal trials for CTC implementation in the routine management of breast cancer patients. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 190 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 2% |
| India | 2 | 1% |
| France | 1 | <1% |
| Colombia | 1 | <1% |
| Mexico | 1 | <1% |
| Egypt | 1 | <1% |
| Spain | 1 | <1% |
| Belgium | 1 | <1% |
| Unknown | 179 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 40 | 21% |
| Student > Ph. D. Student | 34 | 18% |
| Student > Master | 26 | 14% |
| Other | 20 | 11% |
| Student > Bachelor | 12 | 6% |
| Other | 33 | 17% |
| Unknown | 25 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 50 | 26% |
| Agricultural and Biological Sciences | 37 | 19% |
| Biochemistry, Genetics and Molecular Biology | 28 | 15% |
| Engineering | 16 | 8% |
| Chemistry | 6 | 3% |
| Other | 19 | 10% |
| Unknown | 34 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 March 2019.
All research outputs
#3,050,716
of 22,709,015 outputs
Outputs from Cancer and Metastasis Reviews
#69
of 806 outputs
Outputs of similar age
#23,120
of 183,521 outputs
Outputs of similar age from Cancer and Metastasis Reviews
#1
of 11 outputs
Altmetric has tracked 22,709,015 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 806 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 183,521 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.