| Title |
Fragment-based lead discovery: challenges and opportunities
|
|---|---|
| Published in |
Perspectives in Drug Discovery and Design, July 2011
|
| DOI | 10.1007/s10822-011-9451-z |
| Pubmed ID | |
| Authors |
Chaohong Sun, Andrew M. Petros, Philip J. Hajduk |
| Abstract |
Fragment-based lead discovery has undergone remarkable changes over the last 15 years. During this time, the pharmaceutical industry has changed dramatically as well, and continued evolution of the industry is assured. These changes present many challenges but also several opportunities for executing fragment-based drug design. This article will explore some of the more significant changes in the industry and how they may affect future discovery efforts related to fragment-based initiatives. |
Mendeley readers
The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 3% |
| France | 1 | 1% |
| China | 1 | 1% |
| United Kingdom | 1 | 1% |
| Russia | 1 | 1% |
| Poland | 1 | 1% |
| Unknown | 68 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 23 | 31% |
| Student > Ph. D. Student | 16 | 21% |
| Student > Master | 8 | 11% |
| Other | 5 | 7% |
| Student > Bachelor | 4 | 5% |
| Other | 15 | 20% |
| Unknown | 4 | 5% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 26 | 35% |
| Agricultural and Biological Sciences | 21 | 28% |
| Biochemistry, Genetics and Molecular Biology | 7 | 9% |
| Medicine and Dentistry | 4 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
| Other | 7 | 9% |
| Unknown | 7 | 9% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2011.
All research outputs
#4,829,384
of 25,457,297 outputs
Outputs from Perspectives in Drug Discovery and Design
#214
of 949 outputs
Outputs of similar age
#24,461
of 127,806 outputs
Outputs of similar age from Perspectives in Drug Discovery and Design
#11
of 22 outputs
Altmetric has tracked 25,457,297 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 949 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 127,806 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.