| Title |
The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia
|
|---|---|
| Published in |
Acta Neuropathologica, July 2010
|
| DOI | 10.1007/s00401-010-0718-6 |
| Pubmed ID | |
| Authors |
Costantino Iadecola |
| Abstract |
There is increasing evidence that cerebrovascular dysfunction plays a role not only in vascular causes of cognitive impairment but also in Alzheimer's disease (AD). Vascular risk factors and AD impair the structure and function of cerebral blood vessels and associated cells (neurovascular unit), effects mediated by vascular oxidative stress and inflammation. Injury to the neurovascular unit alters cerebral blood flow regulation, depletes vascular reserves, disrupts the blood-brain barrier, and reduces the brain's repair potential, effects that amplify the brain dysfunction and damage exerted by incident ischemia and coexisting neurodegeneration. Clinical-pathological studies support the notion that vascular lesions aggravate the deleterious effects of AD pathology by reducing the threshold for cognitive impairment and accelerating the pace of the dementia. In the absence of mechanism-based approaches to counteract cognitive dysfunction, targeting vascular risk factors and improving cerebrovascular health offers the opportunity to mitigate the impact of one of the most disabling human afflictions. |
Mendeley readers
The data shown below were compiled from readership statistics for 364 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | 1% |
| Italy | 3 | <1% |
| Netherlands | 2 | <1% |
| United States | 2 | <1% |
| Canada | 2 | <1% |
| India | 1 | <1% |
| France | 1 | <1% |
| Austria | 1 | <1% |
| Unknown | 348 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 81 | 22% |
| Researcher | 63 | 17% |
| Student > Master | 46 | 13% |
| Student > Bachelor | 31 | 9% |
| Professor > Associate Professor | 25 | 7% |
| Other | 59 | 16% |
| Unknown | 59 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 88 | 24% |
| Agricultural and Biological Sciences | 51 | 14% |
| Neuroscience | 50 | 14% |
| Biochemistry, Genetics and Molecular Biology | 22 | 6% |
| Psychology | 21 | 6% |
| Other | 53 | 15% |
| Unknown | 79 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 July 2010.
All research outputs
#4,677,977
of 22,709,015 outputs
Outputs from Acta Neuropathologica
#1,044
of 2,360 outputs
Outputs of similar age
#19,666
of 94,932 outputs
Outputs of similar age from Acta Neuropathologica
#5
of 18 outputs
Altmetric has tracked 22,709,015 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,360 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.3. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 94,932 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.