| Title |
Hemagglutinin-esterase-fusion (HEF) protein of influenza C virus
|
|---|---|
| Published in |
Protein & Cell, July 2015
|
| DOI | 10.1007/s13238-015-0193-x |
| Pubmed ID | |
| Authors |
Mingyang Wang, Michael Veit |
| Abstract |
Influenza C virus, a member of the Orthomyxoviridae family, causes flu-like disease but typically only with mild symptoms. Humans are the main reservoir of the virus, but it also infects pigs and dogs. Very recently, influenza C-like viruses were isolated from pigs and cattle that differ from classical influenza C virus and might constitute a new influenza virus genus. Influenza C virus is unique since it contains only one spike protein, the hemagglutinin-esterase-fusion glycoprotein HEF that possesses receptor binding, receptor destroying and membrane fusion activities, thus combining the functions of Hemagglutinin (HA) and Neuraminidase (NA) of influenza A and B viruses. Here we briefly review the epidemiology and pathology of the virus and the morphology of virus particles and their genome. The main focus is on the structure of the HEF protein as well as on its co- and post-translational modification, such as N-glycosylation, disulfide bond formation, S-acylation and proteolytic cleavage into HEF1 and HEF2 subunits. Finally, we describe the functions of HEF: receptor binding, esterase activity and membrane fusion. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 96 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 1 | 1% |
| Unknown | 95 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 17% |
| Researcher | 14 | 15% |
| Student > Bachelor | 13 | 14% |
| Student > Master | 11 | 11% |
| Student > Postgraduate | 7 | 7% |
| Other | 15 | 16% |
| Unknown | 20 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 22 | 23% |
| Immunology and Microbiology | 13 | 14% |
| Agricultural and Biological Sciences | 12 | 13% |
| Medicine and Dentistry | 9 | 9% |
| Chemistry | 6 | 6% |
| Other | 13 | 14% |
| Unknown | 21 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 November 2018.
All research outputs
#6,986,040
of 22,903,988 outputs
Outputs from Protein & Cell
#255
of 740 outputs
Outputs of similar age
#81,037
of 263,519 outputs
Outputs of similar age from Protein & Cell
#3
of 21 outputs
Altmetric has tracked 22,903,988 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 740 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.6. This one has gotten more attention than average, scoring higher than 63% of its peers.
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We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.