Title |
A Comparison of Aerosolization and Homogenization Techniques for Production of Alginate Microparticles for Delivery of Corticosteroids to the Colon
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Published in |
Journal of Pharmaceutical Sciences, September 2016
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DOI | 10.1016/j.xphs.2016.08.015 |
Pubmed ID | |
Authors |
Yassmin O. Samak, Magda El Massik, Allan G.A. Coombes |
Abstract |
Alginate microparticles incorporating hydrocortisone hemisuccinate were produced by aerosolization and homogenization methods to investigate their potential for colonic drug delivery. Microparticle stabilization was achieved by CaCl2 crosslinking solution (0.5 M and 1 M), and drug loading was accomplished by diffusion into blank microparticles or by direct encapsulation. Homogenization method produced smaller microparticles (45-50 μm), compared to aerosolization (65-90 μm). High drug loadings (40% wt/wt) were obtained for diffusion-loaded aerosolized microparticles. Aerosolized microparticles suppressed drug release in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) prior to drug release in simulated colonic fluid (SCF) to a higher extent than homogenized microparticles. Microparticles prepared using aerosolization or homogenization (1 M CaCl2, diffusion loaded) released 5% and 17% of drug content after 2 h in SGF and 4 h in SIF, respectively, and 75% after 12 h in SCF. Thus, aerosolization and homogenization techniques show potential for producing alginate microparticles for colonic drug delivery in the treatment of inflammatory bowel disease. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 2% |
India | 1 | 2% |
Unknown | 40 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 10 | 24% |
Student > Bachelor | 6 | 14% |
Student > Master | 6 | 14% |
Student > Ph. D. Student | 6 | 14% |
Other | 2 | 5% |
Other | 3 | 7% |
Unknown | 9 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 13 | 31% |
Chemical Engineering | 4 | 10% |
Chemistry | 4 | 10% |
Medicine and Dentistry | 3 | 7% |
Agricultural and Biological Sciences | 2 | 5% |
Other | 4 | 10% |
Unknown | 12 | 29% |