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A diabatic three-state representation of photoisomerization in the green fluorescent protein chromophore

Overview of attention for article published in Journal of Chemical Physics, May 2009
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (82nd percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

Mentioned by

blogs
1 blog

Citations

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54 Dimensions

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33 Mendeley
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Title
A diabatic three-state representation of photoisomerization in the green fluorescent protein chromophore
Published in
Journal of Chemical Physics, May 2009
DOI 10.1063/1.3121324
Pubmed ID
Authors

Seth Olsen, Ross H. McKenzie

Abstract

We give a quantum chemical description of the photoisomerization reaction of green fluorescent protein (GFP) chromophores using a representation over three diabatic states. Photoisomerization leads to nonradiative decay, and competes with fluorescence in these systems. In the protein, this pathway is suppressed, leading to fluorescence. Understanding the electronic states relevant to photoisomerization is a prerequisite to understanding how the protein suppresses it, and preserves the emitting state of the chromophore. We present a solution to the state-averaged complete active space problem, which is spanned at convergence by three fragment-localized orbitals. We generate the diabatic-state representation by block diagonalization transformation of the Hamiltonian calculated for the anionic chromophore model HBDI with multireference, multistate perturbation theory. The diabatic states are charge localized and admit a natural valence-bond interpretation. At planar geometries, the diabatic picture of the optical excitation reduces to the canonical two-state charge-transfer resonance of the anion. Extension to a three-state model is necessary to describe decay via two possible pathways associated with photoisomerization of the (methine) bridge. Parametric Hamiltonians based on the three-state ansatz can be fit directly to data generated using the underlying active space. We provide an illustrative example of such a parametric Hamiltonian.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Sweden 1 3%
Italy 1 3%
Belgium 1 3%
Unknown 29 88%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 27%
Student > Ph. D. Student 7 21%
Professor > Associate Professor 4 12%
Other 3 9%
Student > Postgraduate 2 6%
Other 5 15%
Unknown 3 9%
Readers by discipline Count As %
Chemistry 22 67%
Agricultural and Biological Sciences 4 12%
Biochemistry, Genetics and Molecular Biology 2 6%
Materials Science 1 3%
Engineering 1 3%
Other 0 0%
Unknown 3 9%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 July 2015.
All research outputs
#4,699,291
of 25,385,509 outputs
Outputs from Journal of Chemical Physics
#1,616
of 19,829 outputs
Outputs of similar age
#17,930
of 103,680 outputs
Outputs of similar age from Journal of Chemical Physics
#4
of 36 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 19,829 research outputs from this source. They receive a mean Attention Score of 3.2. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 103,680 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.