| Title |
ZURÜCKGEZOGEN: Pathophysiologie und Keimspektrum der Sepsis
|
|---|---|
| Published in |
Die Innere Medizin, May 2009
|
| DOI | 10.1007/s00108-008-2284-8 |
| Pubmed ID | |
| Authors |
H.P. Hauber, P. Zabel |
| Abstract |
The pathophysiology of sepsis is not completely understood. Bacteria are the main cause of sepsis. Activated receptors of the innate immune system lead to an exaggerated immune response. Immune cells including activated neutrophils and macrophages express and are controlled by a variety of cytokines, chemokines, complement factors and other mediators. These proinflammatory factors induce the expression of secondary mediators such as lipids and reactive oxygen species leading to further amplification of inflammation. Due to loss of control mechanisms in sepsis the immune response causes damage of the own organism. The early phase of sepsis is characterized by a proinflammatory response. In contrast, in the late stage of sepsis an anti-inflammatory milieu is observed that can cause severe immunosuppression. An overview will be given on the recent advances in understanding the interaction of different pathophysiological mechanisms and potential therapeutic interventions in the complex and dynamic syndrome of sepsis. |
Mendeley readers
The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 3 | 30% |
| Unknown | 7 | 70% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 4 | 40% |
| Student > Doctoral Student | 2 | 20% |
| Professor | 2 | 20% |
| Student > Ph. D. Student | 1 | 10% |
| Other | 1 | 10% |
| Other | 0 | 0% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 9 | 90% |
| Agricultural and Biological Sciences | 1 | 10% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 June 2011.
All research outputs
#3,798,945
of 25,374,917 outputs
Outputs from Die Innere Medizin
#31
of 495 outputs
Outputs of similar age
#12,901
of 102,428 outputs
Outputs of similar age from Die Innere Medizin
#2
of 6 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 495 research outputs from this source. They receive a mean Attention Score of 4.0. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 102,428 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.