Title |
RETRACTED: Proton-pumping-ATPase-targeted antifungal activity of cinnamaldehyde based sulfonyl tetrazoles
|
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Published in |
European Journal of Medicinal Chemistry, December 2011
|
DOI | 10.1016/j.ejmech.2011.12.007 |
Pubmed ID | |
Authors |
Shreaz, Mohmmad Younus Wani, Rayees Ahmad, Imran Ahmad, Rimple Bhatia, Fareeda Athar, Manzoor Nikhat, Luqman A. Khan |
Abstract |
Azoles are generally fungistatic, and resistance to fluconazole is emerging in several fungal pathogens. We designed a series of cinnamaldehyde based sulfonyl tetrazole derivatives. To further explore the antifungal activity, in vitro studies were conducted against 60 clinical isolates and 6 standard laboratory strains of Candida. The rapid irreversible action of these compounds on fungal cells suggested a membrane-located target for their action. Results obtained indicate plasma membrane H(+)-ATPase as site of action of the synthesized compounds. Inhibition of H(+)-ATPase leads to intracellular acidification and cell death. Presence of chloro and nitro groups on the sulfonyl pendant has been demonstrated to be a key structural element of antifungal potency. SEM micrographs of treated Candida cells showed severe cell breakage and alterations in morphology. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 24 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Doctoral Student | 5 | 21% |
Student > Ph. D. Student | 3 | 13% |
Other | 2 | 8% |
Researcher | 2 | 8% |
Student > Postgraduate | 2 | 8% |
Other | 5 | 21% |
Unknown | 5 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 9 | 38% |
Medicine and Dentistry | 2 | 8% |
Arts and Humanities | 1 | 4% |
Environmental Science | 1 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
Other | 2 | 8% |
Unknown | 8 | 33% |