| Title |
Adherence Support Approaches in Biomedical HIV Prevention Trials: Experiences, Insights and Future Directions from Four Multisite Prevention Trials
|
|---|---|
| Published in |
AIDS and Behavior, February 2013
|
| DOI | 10.1007/s10461-013-0429-9 |
| Pubmed ID | |
| Authors |
K. Rivet Amico, Leila E. Mansoor, Amy Corneli, Kristine Torjesen, Ariane van der Straten |
| Abstract |
Adherence is a critical component of the success of antiretroviral-based pre-exposure prophylaxis (PrEP) in averting new HIV-infections. Ensuring drug availability at the time of potential HIV exposure relies on self-directed product use. A deeper understanding of how to best support sustained PrEP adherence remains critical to current and future PrEP efforts. This paper provides a succinct synthesis of the adherence support experiences from four pivotal PrEP trials--Centre for the AIDS Programme of Research in South Africa (CAPRISA) 004, FEM-PrEP, Iniciativa Prophylaxis (iPrEx), and Vaginal and Oral Interventions to Control the Epidemic (VOICE). Notwithstanding variability in the design, population/cohort, formulation, drug, dosing strategy, and operationalization of adherence approaches utilized in each trial, the theoretical basis and experiences in implementation and monitoring of the approaches used by these trials provide key lessons for optimizing adherence in future research and programmatic scale-up of PrEP. Recommendations from across these trials include participant-centered approaches, separating measurement of adherence from adherence counseling, incorporating tailored strategies that go beyond education, fostering motivation, and addressing the specific context in which an individual incorporates and negotiates PrEP use. |
X Demographics
The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 70% |
| United Kingdom | 1 | 10% |
| Unknown | 2 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 80% |
| Practitioners (doctors, other healthcare professionals) | 1 | 10% |
| Science communicators (journalists, bloggers, editors) | 1 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 171 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 2% |
| United Kingdom | 1 | <1% |
| Unknown | 167 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 33 | 19% |
| Researcher | 25 | 15% |
| Student > Ph. D. Student | 20 | 12% |
| Student > Bachelor | 17 | 10% |
| Student > Doctoral Student | 12 | 7% |
| Other | 34 | 20% |
| Unknown | 30 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 50 | 29% |
| Social Sciences | 26 | 15% |
| Nursing and Health Professions | 17 | 10% |
| Psychology | 17 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 4% |
| Other | 17 | 10% |
| Unknown | 37 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 February 2015.
All research outputs
#4,381,927
of 23,849,058 outputs
Outputs from AIDS and Behavior
#641
of 3,566 outputs
Outputs of similar age
#35,543
of 195,598 outputs
Outputs of similar age from AIDS and Behavior
#11
of 61 outputs
Altmetric has tracked 23,849,058 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,566 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has done well, scoring higher than 82% of its peers.
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We're also able to compare this research output to 61 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.