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Attention Score in Context
| Title |
Regional selection of the brain size regulating gene CASC5 provides new insight into human brain evolution
|
|---|---|
| Published in |
Human Genetics, November 2016
|
| DOI | 10.1007/s00439-016-1748-5 |
| Pubmed ID | |
| Authors |
Lei Shi, Enzhi Hu, Zhenbo Wang, Jiewei Liu, Jin Li, Ming Li, Hua Chen, Chunshui Yu, Tianzi Jiang, Bing Su |
| Abstract |
Human evolution is marked by a continued enlargement of the brain. Previous studies on human brain evolution focused on identifying sequence divergences of brain size regulating genes between humans and nonhuman primates. However, the evolutionary pattern of the brain size regulating genes during recent human evolution is largely unknown. We conducted a comprehensive analysis of the brain size regulating gene CASC5 and found that in recent human evolution, CASC5 has accumulated many modern human specific amino acid changes, including two fixed changes and six polymorphic changes. Among human populations, 4 of the 6 amino acid polymorphic sites have high frequencies of derived alleles in East Asians, but are rare in Europeans and Africans. We proved that this between-population allelic divergence was caused by regional Darwinian positive selection in East Asians. Further analysis of brain image data of Han Chinese showed significant associations of the amino acid polymorphic sites with gray matter volume. Hence, CASC5 may contribute to the morphological and structural changes of the human brain during recent evolution. The observed between-population divergence of CASC5 variants was driven by natural selection that tends to favor a larger gray matter volume in East Asians. |
X Demographics
The data shown below were collected from the profiles of 20 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 5% |
| Germany | 1 | 5% |
| Denmark | 1 | 5% |
| South Africa | 1 | 5% |
| Russia | 1 | 5% |
| Australia | 1 | 5% |
| Unknown | 14 | 70% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 18 | 90% |
| Scientists | 1 | 5% |
| Science communicators (journalists, bloggers, editors) | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 3% |
| Unknown | 36 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 9 | 24% |
| Researcher | 7 | 19% |
| Professor > Associate Professor | 4 | 11% |
| Student > Ph. D. Student | 3 | 8% |
| Student > Postgraduate | 3 | 8% |
| Other | 3 | 8% |
| Unknown | 8 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 8 | 22% |
| Medicine and Dentistry | 4 | 11% |
| Agricultural and Biological Sciences | 4 | 11% |
| Neuroscience | 3 | 8% |
| Social Sciences | 3 | 8% |
| Other | 7 | 19% |
| Unknown | 8 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 36. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 October 2023.
All research outputs
#1,131,945
of 25,658,139 outputs
Outputs from Human Genetics
#86
of 2,975 outputs
Outputs of similar age
#22,341
of 417,212 outputs
Outputs of similar age from Human Genetics
#1
of 14 outputs
Altmetric has tracked 25,658,139 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,975 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 417,212 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.