Title |
Depressed lymphocyte responsiveness in autistic children
|
---|---|
Published in |
Journal of Autism and Developmental Disorders, March 1977
|
DOI | 10.1007/bf01531114 |
Pubmed ID | |
Authors |
E. Gene Stubbs, Mary Lou Crawford, Denis R. Burger, Arthur A. Vandenbark |
Abstract |
Although there are associations linking autism with prenatal rubella, cytomegalovirus, syphilis, and varicella, the etiology of the autistic state remains obscure. Host defense against the etiologic agents postulated to be responsible for the autism-associated syndromes is believed to be primarily of the cell-mediated type. In this preliminary study, cellular immune function was assessed in vitro by phytohemagglutinin (PHA) stimulation of lymphocyte cultures. Twelve autistic children and 13 control subjects were compared. The autistic group exhibited a depressed lymphocyte transformation response to PHA when compared to the control subjects (p less than .01). |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Iran, Islamic Republic of | 1 | 2% |
United States | 1 | 2% |
Unknown | 53 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 18% |
Student > Master | 10 | 18% |
Professor > Associate Professor | 5 | 9% |
Researcher | 4 | 7% |
Student > Bachelor | 3 | 5% |
Other | 10 | 18% |
Unknown | 13 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 7 | 13% |
Neuroscience | 7 | 13% |
Medicine and Dentistry | 7 | 13% |
Biochemistry, Genetics and Molecular Biology | 7 | 13% |
Psychology | 3 | 5% |
Other | 8 | 15% |
Unknown | 16 | 29% |