| Title |
Antimicrobial activity and safety evaluation of peptides isolated from the hemoglobin of chickens
|
|---|---|
| Published in |
BMC Microbiology, December 2016
|
| DOI | 10.1186/s12866-016-0904-3 |
| Pubmed ID | |
| Authors |
Fengjiao Hu, Qiaoxing Wu, Shuang Song, Ruiping She, Yue Zhao, Yifei Yang, Meikun Zhang, Fang Du, Majid Hussain Soomro, Ruihan Shi |
| Abstract |
Hemoglobin is a rich source of biological peptides. As a byproduct and even wastewater of poultry-slaughtering facilities, chicken blood is one of the most abundant source of hemoglobin. In this study, the chicken hemoglobin antimicrobial peptides (CHAP) were isolated and the antimicrobial and bactericidal activities were tested by the agarose diffusion assay, minimum inhibitory concentration (MIC) analysis, minimal bactericidal concentration (MBC) analysis, and time-dependent inhibitory and bactericidal assays. The results demonstrated that CHAP had potent and rapid antimicrobial activity against 19 bacterial strains, including 9 multidrug-resistant bacterial strains. Bacterial biofilm and NaCl permeability assays, transmission electron microscopy (TEM) and scanning electron microscopy (SEM) were further performed to detect the mechanism of its antimicrobial effect. Additionally, CHAP showed low hemolytic activity, embryo toxicity, and high stability in different temperatures and animal plasma. CHAP may have great potential for expanding production and development value in animal medication, the breeding industry and environment protection. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 17% |
| Kenya | 1 | 17% |
| Venezuela, Bolivarian Republic of | 1 | 17% |
| Unknown | 3 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 50% |
| Scientists | 3 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 71 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 18% |
| Student > Master | 8 | 11% |
| Student > Bachelor | 8 | 11% |
| Researcher | 7 | 10% |
| Student > Doctoral Student | 6 | 8% |
| Other | 6 | 8% |
| Unknown | 23 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 13 | 18% |
| Agricultural and Biological Sciences | 8 | 11% |
| Immunology and Microbiology | 5 | 7% |
| Veterinary Science and Veterinary Medicine | 3 | 4% |
| Engineering | 2 | 3% |
| Other | 12 | 17% |
| Unknown | 28 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 December 2016.
All research outputs
#6,823,109
of 22,908,162 outputs
Outputs from BMC Microbiology
#755
of 3,197 outputs
Outputs of similar age
#123,909
of 415,991 outputs
Outputs of similar age from BMC Microbiology
#14
of 53 outputs
Altmetric has tracked 22,908,162 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 3,197 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 415,991 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 53 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.