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Immunometabolic Pathways in BCG-Induced Trained Immunity

Overview of attention for article published in Cell Reports, December 2016
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

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Title
Immunometabolic Pathways in BCG-Induced Trained Immunity
Published in
Cell Reports, December 2016
DOI 10.1016/j.celrep.2016.11.011
Pubmed ID
Authors

Rob J.W. Arts, Agostinho Carvalho, Claudia La Rocca, Carla Palma, Fernando Rodrigues, Ricardo Silvestre, Johanneke Kleinnijenhuis, Ekta Lachmandas, Luís G. Gonçalves, Ana Belinha, Cristina Cunha, Marije Oosting, Leo A.B. Joosten, Giuseppe Matarese, Reinout van Crevel, Mihai G. Netea

Abstract

The protective effects of the tuberculosis vaccine Bacillus Calmette-Guerin (BCG) on unrelated infections are thought to be mediated by long-term metabolic changes and chromatin remodeling through histone modifications in innate immune cells such as monocytes, a process termed trained immunity. Here, we show that BCG induction of trained immunity in monocytes is accompanied by a strong increase in glycolysis and, to a lesser extent, glutamine metabolism, both in an in-vitro model and after vaccination of mice and humans. Pharmacological and genetic modulation of rate-limiting glycolysis enzymes inhibits trained immunity, changes that are reflected by the effects on the histone marks (H3K4me3 and H3K9me3) underlying BCG-induced trained immunity. These data demonstrate that a shift of the glucose metabolism toward glycolysis is crucial for the induction of the histone modifications and functional changes underlying BCG-induced trained immunity. The identification of these pathways may be a first step toward vaccines that combine immunological and metabolic stimulation.

X Demographics

X Demographics

The data shown below were collected from the profiles of 15 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 552 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 <1%
Unknown 551 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 91 16%
Researcher 78 14%
Student > Bachelor 72 13%
Student > Master 58 11%
Student > Doctoral Student 30 5%
Other 64 12%
Unknown 159 29%
Readers by discipline Count As %
Immunology and Microbiology 114 21%
Biochemistry, Genetics and Molecular Biology 96 17%
Medicine and Dentistry 61 11%
Agricultural and Biological Sciences 58 11%
Chemistry 9 2%
Other 47 9%
Unknown 167 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 105. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 July 2023.
All research outputs
#398,598
of 25,373,627 outputs
Outputs from Cell Reports
#699
of 12,955 outputs
Outputs of similar age
#8,196
of 420,272 outputs
Outputs of similar age from Cell Reports
#15
of 264 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,955 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 30.3. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 420,272 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 264 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.