Title |
Loss of Bladder Epithelium Induced by Cytolytic Mast Cell Granules
|
---|---|
Published in |
Immunity, December 2016
|
DOI | 10.1016/j.immuni.2016.11.003 |
Pubmed ID | |
Authors |
Hae Woong Choi, Samantha E. Bowen, Yuxuan Miao, Cheryl Y. Chan, Edward A. Miao, Magnus Abrink, Adam J. Moeser, Soman N. Abraham |
Abstract |
Programmed death and shedding of epithelial cells is a powerful defense mechanism to reduce bacterial burden during infection but this activity cannot be indiscriminate because of the critical barrier function of the epithelium. We report that during cystitis, shedding of infected bladder epithelial cells (BECs) was preceded by the recruitment of mast cells (MCs) directly underneath the superficial epithelium where they docked and extruded their granules. MCs were responding to interleukin-1β (IL-1β) secreted by BECs after inflammasome and caspase-1 signaling. Upon uptake of granule-associated chymase (mouse MC protease 4 [mMCPT4]), BECs underwent caspase-1-associated cytolysis and exfoliation. Thus, infected epithelial cells require a specific cue for cytolysis from recruited sentinel inflammatory cells before shedding. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 6 | 30% |
Ireland | 2 | 10% |
Malaysia | 1 | 5% |
United Kingdom | 1 | 5% |
Mexico | 1 | 5% |
France | 1 | 5% |
Unknown | 8 | 40% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 14 | 70% |
Scientists | 5 | 25% |
Science communicators (journalists, bloggers, editors) | 1 | 5% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 76 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 16 | 21% |
Student > Bachelor | 11 | 14% |
Researcher | 8 | 11% |
Professor > Associate Professor | 7 | 9% |
Other | 6 | 8% |
Other | 12 | 16% |
Unknown | 16 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 23 | 30% |
Biochemistry, Genetics and Molecular Biology | 13 | 17% |
Agricultural and Biological Sciences | 10 | 13% |
Medicine and Dentistry | 5 | 7% |
Arts and Humanities | 1 | 1% |
Other | 2 | 3% |
Unknown | 22 | 29% |