| Title |
Sex-biased gene expression in the developing brain: implications for autism spectrum disorders
|
|---|---|
| Published in |
Molecular Autism, May 2013
|
| DOI | 10.1186/2040-2392-4-10 |
| Pubmed ID | |
| Authors |
Mark N Ziats, Owen M Rennert |
| Abstract |
Autism spectrum disorders affect significantly more males than females. Understanding sex differences in normal human brain development may provide insight into the mechanism(s) underlying this disparity; however, studies of sex differences in brain development at the genomic level are lacking. Here, we report a re-analysis of sex-specific gene expression from a recent large transcriptomic study of normal human brain development, to determine whether sex-biased genes relate to specific mechanistic processes. We discovered that male-biased genes are enriched for the processes of extracellular matrix formation/glycoproteins, immune response, chromatin, and cell cytoskeleton. We highlight that these pathways have been repeatedly implicated in autism and demonstrate that autism candidate genes are also enriched for these pathways. We propose that the overlap of these male-specific brain transcriptional modules with the same pathways in autism spectrum disorders may partially explain the increased incidence of autism in males. |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 27% |
| United States | 1 | 9% |
| Italy | 1 | 9% |
| Unknown | 6 | 55% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 64% |
| Science communicators (journalists, bloggers, editors) | 2 | 18% |
| Scientists | 2 | 18% |
Mendeley readers
The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 1% |
| Unknown | 80 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 16 | 20% |
| Student > Master | 10 | 12% |
| Student > Bachelor | 10 | 12% |
| Student > Ph. D. Student | 9 | 11% |
| Student > Doctoral Student | 7 | 9% |
| Other | 20 | 25% |
| Unknown | 9 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 18 | 22% |
| Agricultural and Biological Sciences | 17 | 21% |
| Psychology | 12 | 15% |
| Medicine and Dentistry | 10 | 12% |
| Biochemistry, Genetics and Molecular Biology | 7 | 9% |
| Other | 5 | 6% |
| Unknown | 12 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 November 2018.
All research outputs
#6,583,045
of 25,654,806 outputs
Outputs from Molecular Autism
#427
of 722 outputs
Outputs of similar age
#51,887
of 205,927 outputs
Outputs of similar age from Molecular Autism
#11
of 14 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 722 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.7. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 205,927 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.