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A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression

Overview of attention for article published in Alzheimer's & Dementia: the Journal of the Alzheimer's Association, December 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (63rd percentile)

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1 news outlet
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11 X users
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1 patent

Citations

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48 Dimensions

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97 Mendeley
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Title
A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression
Published in
Alzheimer's & Dementia: the Journal of the Alzheimer's Association, December 2016
DOI 10.1016/j.jalz.2016.10.005
Pubmed ID
Authors

Minerva M. Carrasquillo, Mariet Allen, Jeremy D. Burgess, Xue Wang, Samantha L. Strickland, Shivani Aryal, Joanna Siuda, Michaela L. Kachadoorian, Christopher Medway, Curtis S. Younkin, Asha Nair, Chen Wang, Pritha Chanana, Daniel Serie, Thuy Nguyen, Sarah Lincoln, Kimberly G. Malphrus, Kevin Morgan, Todd E. Golde, Nathan D. Price, Charles C. White, Philip L. De Jager, David A. Bennett, Yan W. Asmann, Julia E. Crook, Ronald C. Petersen, Neill R. Graff‐Radford, Dennis W. Dickson, Steven G. Younkin, Nilüfer Ertekin‐Taner

Abstract

We hypothesized that common Alzheimer's disease (AD)-associated variants within the triggering receptor expressed on myeloid (TREM) gene cluster influence disease through gene expression. Expression microarrays on temporal cortex and cerebellum from ∼400 neuropathologically diagnosed subjects and two independent RNAseq replication cohorts were used for expression quantitative trait locus analysis. A variant within a DNase hypersensitive site 5' of TREM2, rs9357347-C, associates with reduced AD risk and increased TREML1 and TREM2 levels (uncorrected P = 6.3 × 10(-3) and 4.6 × 10(-2), respectively). Meta-analysis on expression quantitative trait locus results from three independent data sets (n = 1006) confirmed these associations (uncorrected P = 3.4 × 10(-2) and 3.5 × 10(-3), Bonferroni-corrected P = 6.7 × 10(-2) and 7.1 × 10(-3), respectively). Our findings point to rs9357347 as a functional regulatory variant that contributes to a protective effect observed at the TREM locus in the International Genomics of Alzheimer's Project genome-wide association study meta-analysis and suggest concomitant increase in TREML1 and TREM2 brain levels as a potential mechanism for protection from AD.

X Demographics

X Demographics

The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 97 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 97 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 21 22%
Student > Ph. D. Student 17 18%
Student > Bachelor 11 11%
Student > Master 8 8%
Student > Postgraduate 5 5%
Other 11 11%
Unknown 24 25%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 21 22%
Agricultural and Biological Sciences 17 18%
Neuroscience 16 16%
Medicine and Dentistry 5 5%
Immunology and Microbiology 3 3%
Other 9 9%
Unknown 26 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 October 2022.
All research outputs
#1,935,312
of 25,374,917 outputs
Outputs from Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#902
of 4,060 outputs
Outputs of similar age
#37,626
of 420,311 outputs
Outputs of similar age from Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#11
of 30 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,060 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 32.3. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 420,311 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.