| Title |
Moderate exercise ameliorates dysregulated hippocampal glycometabolism and memory function in a rat model of type 2 diabetes
|
|---|---|
| Published in |
Diabetologia, December 2016
|
| DOI | 10.1007/s00125-016-4164-4 |
| Pubmed ID | |
| Authors |
Takeru Shima, Takashi Matsui, Subrina Jesmin, Masahiro Okamoto, Mariko Soya, Koshiro Inoue, Yu-Fan Liu, Ignacio Torres-Aleman, Bruce S. McEwen, Hideaki Soya |
| Abstract |
Type 2 diabetes is likely to be an independent risk factor for hippocampal-based memory dysfunction, although this complication has yet to be investigated in detail. As dysregulated glycometabolism in peripheral tissues is a key symptom of type 2 diabetes, it is hypothesised that diabetes-mediated memory dysfunction is also caused by hippocampal glycometabolic dysfunction. If so, such dysfunction should also be ameliorated with moderate exercise by normalising hippocampal glycometabolism, since 4 weeks of moderate exercise enhances memory function and local hippocampal glycogen levels in normal animals. The hippocampal glycometabolism in OLETF rats (model of human type 2 diabetes) was assessed and, subsequently, the effects of exercise on memory function and hippocampal glycometabolism were investigated. OLETF rats, which have memory dysfunction, exhibited higher levels of glycogen in the hippocampus than did control rats, and breakdown of hippocampal glycogen with a single bout of exercise remained unimpaired. However, OLETF rats expressed lower levels of hippocampal monocarboxylate transporter 2 (MCT2, a transporter for lactate to neurons). Four weeks of moderate exercise improved spatial memory accompanied by further increase in hippocampal glycogen levels and restoration of MCT2 expression independent of neurotrophic factor and clinical symptoms in OLETF rats. Our findings are the first to describe detailed profiles of glycometabolism in the type 2 diabetic hippocampus and to show that 4 weeks of moderate exercise improves memory dysfunction in type 2 diabetes via amelioration of dysregulated hippocampal glycometabolism. Dysregulated hippocampal lactate-transport-related glycometabolism is a possible aetiology of type-2-diabetes-mediated memory dysfunction. |
X Demographics
The data shown below were collected from the profiles of 30 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 5 | 17% |
| United States | 4 | 13% |
| Italy | 1 | 3% |
| Saudi Arabia | 1 | 3% |
| Oman | 1 | 3% |
| Germany | 1 | 3% |
| Spain | 1 | 3% |
| Japan | 1 | 3% |
| Kenya | 1 | 3% |
| Other | 3 | 10% |
| Unknown | 11 | 37% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 21 | 70% |
| Scientists | 5 | 17% |
| Practitioners (doctors, other healthcare professionals) | 4 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 93 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 15% |
| Researcher | 13 | 14% |
| Student > Master | 13 | 14% |
| Student > Bachelor | 11 | 12% |
| Professor | 5 | 5% |
| Other | 14 | 15% |
| Unknown | 23 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 15 | 16% |
| Sports and Recreations | 15 | 16% |
| Medicine and Dentistry | 14 | 15% |
| Biochemistry, Genetics and Molecular Biology | 7 | 8% |
| Nursing and Health Professions | 6 | 6% |
| Other | 8 | 9% |
| Unknown | 28 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 135. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 October 2017.
All research outputs
#282,925
of 24,037,100 outputs
Outputs from Diabetologia
#166
of 5,207 outputs
Outputs of similar age
#6,184
of 426,838 outputs
Outputs of similar age from Diabetologia
#6
of 68 outputs
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