| Title |
Coffee and oxidative stress: a human intervention study
|
|---|---|
| Published in |
European Journal of Nutrition, November 2016
|
| DOI | 10.1007/s00394-016-1336-4 |
| Pubmed ID | |
| Authors |
Sergey Shaposhnikov, Thomas Hatzold, Naouale El Yamani, Philip Mark Stavro, Yolanda Lorenzo, Maria Dusinska, Astrid Reus, Wilrike Pasman, Andrew Collins |
| Abstract |
Coffee is known to contain phytochemicals with antioxidant potential. The aim of this study was to investigate possible antioxidant effects of coffee in healthy human volunteers. A placebo-controlled intervention trial was carried out on 160 healthy human subjects, randomised into three groups, receiving 3 or 5 cups of study coffee or water per day, for 8 weeks. Blood samples were taken before, during, and after the intervention. Serum was used for analysis of blood lipids and standard clinical chemistry analytes. Peripheral blood mononuclear cells were isolated, and DNA damage (strand breaks and oxidised bases) was measured with the comet assay. The lipid oxidation product isoprostane 8-iso-PGF2α was assayed in urine samples by LC-MS/MS. There was no significant effect of coffee consumption on the markers of oxidation of DNA and lipids. Creatinine (in serum) increased by a few per cent in all groups, and the liver enzyme γ-glutamyl transaminase was significantly elevated in serum in the 5 cups/day group. Other clinical markers (including glucose and insulin), cholesterol, triacylglycerides, and inflammatory markers were unchanged. There was no effect of coffee on blood pressure. In a carefully controlled clinical trial with healthy subjects, up to 5 cups of coffee per day had no detectable effect, either beneficial or harmful, on human health. |
X Demographics
The data shown below were collected from the profiles of 28 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 18% |
| United Kingdom | 3 | 11% |
| South Africa | 2 | 7% |
| Iraq | 1 | 4% |
| Cameroon | 1 | 4% |
| Australia | 1 | 4% |
| Saudi Arabia | 1 | 4% |
| Bosnia and Herzegovina | 1 | 4% |
| Unknown | 13 | 46% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 22 | 79% |
| Practitioners (doctors, other healthcare professionals) | 4 | 14% |
| Science communicators (journalists, bloggers, editors) | 1 | 4% |
| Scientists | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 117 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 117 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 19 | 16% |
| Student > Master | 16 | 14% |
| Researcher | 15 | 13% |
| Student > Ph. D. Student | 9 | 8% |
| Student > Postgraduate | 5 | 4% |
| Other | 13 | 11% |
| Unknown | 40 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 25 | 21% |
| Nursing and Health Professions | 14 | 12% |
| Biochemistry, Genetics and Molecular Biology | 8 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 6% |
| Agricultural and Biological Sciences | 5 | 4% |
| Other | 10 | 9% |
| Unknown | 48 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 57. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 April 2024.
All research outputs
#757,936
of 25,658,541 outputs
Outputs from European Journal of Nutrition
#212
of 2,706 outputs
Outputs of similar age
#15,446
of 419,584 outputs
Outputs of similar age from European Journal of Nutrition
#5
of 37 outputs
Altmetric has tracked 25,658,541 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,706 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.6. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 419,584 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.