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HER2-Orientated Therapy in Early and Metastatic Breast Cancer

Overview of attention for article published in Breast Care, December 2016
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1 X user

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Title
HER2-Orientated Therapy in Early and Metastatic Breast Cancer
Published in
Breast Care, December 2016
DOI 10.1159/000453603
Pubmed ID
Authors

Severine Iborra, Elmar Stickeler

Abstract

Due to the enhanced understanding of molecular oncology and signaling pathways in breast cancer (BC), therapy management has undergone a major transformation, especially with the emergence of treatment tailored to individual disease characteristics. In the case of HER2-positive early or metastatic BC, targeted therapies are well established and remain a major focus of ongoing research. The introduction of anti-HER2 biologicals such as trastuzumab, pertuzumab, and T-DM1 has made targeted and personalized treatment possible and has clearly improved disease-free and overall survival in patients with HER2-positive BC. Moreover, neoadjuvant chemotherapy represents a well-established and often favored option for patients with operable BC and a clear indication for postoperative chemotherapy (such as HER2-positive BC). Other trials are trying to identify additional surrogate markers for therapy response and clinical outcome in the neoadjuvant setting and that way open up new perspectives with a possible de-escalation of classical treatment in favor of targeted therapy.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 33 100%

Demographic breakdown

Readers by professional status Count As %
Other 6 18%
Student > Bachelor 6 18%
Researcher 5 15%
Student > Postgraduate 4 12%
Student > Ph. D. Student 3 9%
Other 3 9%
Unknown 6 18%
Readers by discipline Count As %
Medicine and Dentistry 11 33%
Pharmacology, Toxicology and Pharmaceutical Science 5 15%
Biochemistry, Genetics and Molecular Biology 4 12%
Agricultural and Biological Sciences 3 9%
Unspecified 1 3%
Other 0 0%
Unknown 9 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 December 2016.
All research outputs
#18,490,948
of 22,912,409 outputs
Outputs from Breast Care
#250
of 377 outputs
Outputs of similar age
#308,038
of 419,640 outputs
Outputs of similar age from Breast Care
#9
of 12 outputs
Altmetric has tracked 22,912,409 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 377 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 419,640 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.