| Title |
Association Between Exercise-Induced Hyperthermia and Intestinal Permeability: A Systematic Review
|
|---|---|
| Published in |
Sports Medicine, December 2016
|
| DOI | 10.1007/s40279-016-0654-2 |
| Pubmed ID | |
| Authors |
Washington Pires, Christiano E. Veneroso, Samuel P. Wanner, Diogo A. S. Pacheco, Gisele C. Vaz, Fabiano T. Amorim, Cajsa Tonoli, Danusa D. Soares, Cândido C. Coimbra |
| Abstract |
Prolonged and strenuous physical exercise increases intestinal permeability, allowing luminal endotoxins to translocate through the intestinal barrier and reach the bloodstream. When recognized by the immune system, these endotoxins trigger a systemic inflammatory response that may affect physical performance and, in severe cases, induce heat stroke. However, it remains to be elucidated whether there is a relationship between the magnitude of exercise-induced hyperthermia and changes in intestinal permeability. In this systematic review, we evaluated whether an exercise-induced increase in core body temperature (T Core) is associated with an exercise-induced increase in intestinal permeability. The present systematic review screened the MEDLINE/PubMed and Web of Science databases in September 2016, without any date restrictions. Sixteen studies that were performed in healthy participants, presented original data, and measured both the exercise-induced changes in T Core and intestinal permeability were selected. These studies assessed intestinal permeability through the measurement of sugar levels in the urine and measurement of intestinal fatty acid binding protein or lipopolysaccharide levels in the blood. Exercise increased both T Core and intestinal permeability in most of the 16 studies. In addition, a positive and strong correlation was observed between the two parameters (r = 0.793; p < 0.001), and a T Core exceeding 39 °C was always associated with augmented permeability. The magnitude of exercise-induced hyperthermia is directly associated with the increase in intestinal permeability. |
X Demographics
The data shown below were collected from the profiles of 23 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 17% |
| Australia | 3 | 13% |
| United Kingdom | 3 | 13% |
| Canada | 2 | 9% |
| Portugal | 1 | 4% |
| Taiwan | 1 | 4% |
| Netherlands | 1 | 4% |
| Comoros | 1 | 4% |
| Mexico | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 6 | 26% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 10 | 43% |
| Practitioners (doctors, other healthcare professionals) | 7 | 30% |
| Scientists | 5 | 22% |
| Science communicators (journalists, bloggers, editors) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 141 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| Unknown | 140 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 16% |
| Student > Master | 16 | 11% |
| Researcher | 15 | 11% |
| Student > Bachelor | 14 | 10% |
| Student > Doctoral Student | 11 | 8% |
| Other | 32 | 23% |
| Unknown | 31 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Sports and Recreations | 29 | 21% |
| Medicine and Dentistry | 23 | 16% |
| Nursing and Health Professions | 15 | 11% |
| Biochemistry, Genetics and Molecular Biology | 13 | 9% |
| Agricultural and Biological Sciences | 5 | 4% |
| Other | 17 | 12% |
| Unknown | 39 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 December 2017.
All research outputs
#2,301,885
of 23,577,654 outputs
Outputs from Sports Medicine
#1,447
of 2,744 outputs
Outputs of similar age
#47,459
of 422,783 outputs
Outputs of similar age from Sports Medicine
#30
of 41 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,744 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 52.4. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 422,783 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.