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Neurohormonal Activation After Atrial Fibrillation Initiation in Patients Eligible for Catheter Ablation: A Randomized Controlled Study

Overview of attention for article published in Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, December 2016
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Title
Neurohormonal Activation After Atrial Fibrillation Initiation in Patients Eligible for Catheter Ablation: A Randomized Controlled Study
Published in
Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, December 2016
DOI 10.1161/jaha.116.003957
Pubmed ID
Authors

Emmanouil Charitakis, Håkan Walfridsson, Eva Nylander, Urban Alehagen

Abstract

Biomarker activation in atrial fibrillation (AF) has been widely studied, but the immediate effect of AF initiation remains unclear. We studied the effect of AF initiation on 2 cardiac biomarkers: the N-terminal fragment of the proB-type natriuretic peptide (NT-proBNP), the midregional fragment of the N-terminal of pro-atrial natriuretic peptide (MR-proANP), and 2 extracardiac biomarkers-the copeptin and the midregional portion of proadrenomedullin (MR-proADM). This was a randomized controlled study, including 45 patients with AF who had been referred for radiofrequency ablation to the University Hospital, Linköping, Sweden, between February 2012 and April 2014. Freedom from AF during the 4 days prior to radiofrequency ablation was confirmed by transtelephonic ECGs. Biomarkers were collected from the femoral vein (fv), coronary sinus (CS), and left atrium (LA) prior to AF initiation (baseline) and 30 minutes later. The MR-proANP and NT-proBNP concentrations increased in the intervention group compared with the control group 30 minutes after the initiation of AF (MR-proANP: Pfv<0.001, PCS<0.001, PLA<0.001; NT-proBNP: PLA<0.001). Copeptin levels in patients without ischemic heart disease were decreased after the initiation of AF (Pfv=0.003, PCS=0.015, PLA=0.011). AF is a strong stimulus that results in immediate activation of different biomarkers. URL: http://www.clinicaltrials.gov. Unique identifier: NCT01553045.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 39 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 5 13%
Student > Master 5 13%
Other 4 10%
Student > Ph. D. Student 4 10%
Student > Bachelor 4 10%
Other 6 15%
Unknown 11 28%
Readers by discipline Count As %
Medicine and Dentistry 17 44%
Biochemistry, Genetics and Molecular Biology 1 3%
Business, Management and Accounting 1 3%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Agricultural and Biological Sciences 1 3%
Other 3 8%
Unknown 15 38%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 December 2016.
All research outputs
#14,772,826
of 25,377,790 outputs
Outputs from Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease
#5,420
of 8,237 outputs
Outputs of similar age
#216,714
of 419,629 outputs
Outputs of similar age from Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease
#70
of 114 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,237 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 31.6. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 419,629 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 114 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.