Transducin-like enhancer protein 1 mediates estrogen receptor binding and transcriptional activity in breast cancer cells

Overview of attention for article published in Proceedings of the National Academy of Sciences of the United States of America, May 2011

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Good Attention Score compared to outputs of the same age (65th percentile)
Average Attention Score compared to outputs of the same age and source

Mentioned by

blogs: 1 blog

Readers on

mendeley: 117 Mendeley

Article details
Title	Transducin-like enhancer protein 1 mediates estrogen receptor binding and transcriptional activity in breast cancer cells
Published in	Proceedings of the National Academy of Sciences of the United States of America, May 2011
DOI	10.1073/pnas.1018863108
Pubmed ID	21536917
Authors	Kelly A. Holmes, Antoni Hurtado, Gordon D. Brown, Rosalind Launchbury, Caryn S. Ross-Innes, James Hadfield, Duncan T. Odom, Jason S. Carroll
Abstract	Estrogen receptor (ER) binds to distal enhancers within the genome and requires additional factors, such as the Forkhead protein FoxA1, for mediating chromatin interactions. We now show that the human Groucho protein, Transducin-like enhancer protein 1 (TLE1), positively assists some ER-chromatin interactions, a role that is distinct from its general role as a transcriptional repressor. We show that specific silencing of TLE1 inhibits the ability of ER to bind to a subset of ER binding sites within the genome, a phenomenon that results in perturbations in phospho-RNA Pol II recruitment. Furthermore, TLE1 is essential for effective ER-mediated cell division. We have discovered a distinct role for TLE1, as a necessary transcriptional component of the ER complex, where it facilitates ER-chromatin interactions.

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Timeline

Attention over time

Attention Score history

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Mendeley readers

The data shown below were compiled from readership statistics for 117 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Geographical breakdown
Country	Count	As %
United States	1	<1%
Latvia	1	<1%
Unknown	115	98%

Demographic breakdown

Readers by professional status
Readers by professional status	Count	As %
Researcher	36	31%
Other	32	27%
Student > Ph. D. Student	16	14%
Student > Bachelor	6	5%
Professor > Associate Professor	6	5%
Other	9	8%
Unknown	12	10%

Readers by discipline
Readers by discipline	Count	As %
Agricultural and Biological Sciences	72	62%
Biochemistry, Genetics and Molecular Biology	14	12%
Medicine and Dentistry	6	5%
Computer Science	4	3%
Chemistry	3	3%
Other	4	3%
Unknown	14	12%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 October 2016.

All research outputs

#9,336,886

of 33,953,699 outputs

Outputs from Proceedings of the National Academy of Sciences of the United States of America

#73,249

of 117,818 outputs

Outputs of similar age

#51,248

of 160,116 outputs

Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America

#466

of 770 outputs

Altmetric has tracked 33,953,699 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.

So far Altmetric has tracked 117,818 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 39.9. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.

Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 160,116 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.

We're also able to compare this research output to 770 others from the same source and published within six weeks on either side of this one. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.