| Title |
Transducin-like enhancer protein 1 mediates estrogen receptor binding and transcriptional activity in breast cancer cells
|
|---|---|
| Published in |
Proceedings of the National Academy of Sciences of the United States of America, May 2011
|
| DOI | 10.1073/pnas.1018863108 |
| Pubmed ID | |
| Authors |
Kelly A. Holmes, Antoni Hurtado, Gordon D. Brown, Rosalind Launchbury, Caryn S. Ross-Innes, James Hadfield, Duncan T. Odom, Jason S. Carroll |
| Abstract |
Estrogen receptor (ER) binds to distal enhancers within the genome and requires additional factors, such as the Forkhead protein FoxA1, for mediating chromatin interactions. We now show that the human Groucho protein, Transducin-like enhancer protein 1 (TLE1), positively assists some ER-chromatin interactions, a role that is distinct from its general role as a transcriptional repressor. We show that specific silencing of TLE1 inhibits the ability of ER to bind to a subset of ER binding sites within the genome, a phenomenon that results in perturbations in phospho-RNA Pol II recruitment. Furthermore, TLE1 is essential for effective ER-mediated cell division. We have discovered a distinct role for TLE1, as a necessary transcriptional component of the ER complex, where it facilitates ER-chromatin interactions. |
Mendeley readers
The data shown below were compiled from readership statistics for 114 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Latvia | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 112 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 35 | 31% |
| Other | 32 | 28% |
| Student > Ph. D. Student | 16 | 14% |
| Student > Bachelor | 6 | 5% |
| Professor > Associate Professor | 6 | 5% |
| Other | 9 | 8% |
| Unknown | 10 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 72 | 63% |
| Biochemistry, Genetics and Molecular Biology | 13 | 11% |
| Medicine and Dentistry | 6 | 5% |
| Computer Science | 4 | 4% |
| Chemistry | 3 | 3% |
| Other | 4 | 4% |
| Unknown | 12 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 October 2016.
All research outputs
#6,497,958
of 24,625,114 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#57,658
of 101,438 outputs
Outputs of similar age
#35,000
of 114,536 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#425
of 711 outputs
Altmetric has tracked 24,625,114 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 101,438 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.8. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 114,536 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 711 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.