| Title |
Differences of DNA methylation profiles between monozygotic twins’ blood samples
|
|---|---|
| Published in |
Molecular Biology Reports, May 2013
|
| DOI | 10.1007/s11033-013-2627-y |
| Pubmed ID | |
| Authors |
Chengtao Li, Shumin Zhao, Na Zhang, Suhua Zhang, Yiping Hou |
| Abstract |
Monozygotic twins (MZs) share an identical genomic sequence, which makes it impossible to discriminate one another with conventional genetic markers like STRs. On the other hand, phenotypic discordance between MZs implies the existence of different epigenetic characteristics. DNA methylation, an essential epigenetic modification, however, might be a potential biomarker to solve the forensic puzzle. In this study, we examined 22 pairs of MZs with a methylation BeadChip including 27,578 CpG sites. The results suggested that MZs exhibited remarkable differences of genome-wide 5-methylcytosine. According to a set of criteria of selection, 92 CpG sites with significant differences of methylation status within MZs were identified from the global epigenome. In conclusion, this pilot study suggested that CpG methylation profile could be a useful biomarker in individual identification of MZs. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 60% |
| Chile | 1 | 20% |
| Unknown | 1 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 3 | 60% |
| Members of the public | 2 | 40% |
Mendeley readers
The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Germany | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 71 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 15 | 20% |
| Student > Bachelor | 14 | 19% |
| Student > Ph. D. Student | 9 | 12% |
| Researcher | 8 | 11% |
| Student > Doctoral Student | 3 | 4% |
| Other | 10 | 14% |
| Unknown | 15 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 25 | 34% |
| Agricultural and Biological Sciences | 20 | 27% |
| Social Sciences | 5 | 7% |
| Medicine and Dentistry | 2 | 3% |
| Chemistry | 2 | 3% |
| Other | 4 | 5% |
| Unknown | 16 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 July 2013.
All research outputs
#2,638,749
of 22,710,079 outputs
Outputs from Molecular Biology Reports
#55
of 2,877 outputs
Outputs of similar age
#23,263
of 193,543 outputs
Outputs of similar age from Molecular Biology Reports
#1
of 20 outputs
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So far Altmetric has tracked 2,877 research outputs from this source. They receive a mean Attention Score of 2.2. This one has done particularly well, scoring higher than 98% of its peers.
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We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.