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Mendeley readers
Attention Score in Context
| Title |
Id3 Maintains Foxp3 Expression in Regulatory T Cells by Controlling a Transcriptional Network of E47, Spi-B, and SOCS3
|
|---|---|
| Published in |
Cell Reports, December 2016
|
| DOI | 10.1016/j.celrep.2016.11.045 |
| Pubmed ID | |
| Authors |
Katharina S. Rauch, Miriam Hils, Ekaterina Lupar, Susana Minguet, Mikael Sigvardsson, Martin E. Rottenberg, Ana Izcue, Christian Schachtrup, Kristina Schachtrup |
| Abstract |
The transcription factor Foxp3 dominantly controls regulatory T (Treg) cell function, and only its continuous expression guarantees the maintenance of full Treg cell-suppressive capacity. However, transcriptional regulators maintaining Foxp3 transcription are incompletely described. Here, we report that high E47 transcription factor activity in Treg cells resulted in unstable Foxp3 expression. Under homeostatic conditions, Treg cells expressed high levels of the E47 antagonist Id3, thus restricting E47 activity and maintaining Foxp3 expression. In contrast, stimulation of Id3-deficient or E47-overexpressing Treg cells resulted in the loss of Foxp3 expression in a subset of Treg cells in vivo and in vitro. Mechanistic analysis indicated that E47 activated expression of the transcription factor Spi-B and the suppressor of cytokine signaling 3 (SOCS3), which both downregulated Foxp3 expression. These findings demonstrate that the balance of Id3 and E47 controls the maintenance of Foxp3 expression in Treg cells and, thus, contributes to Treg cell plasticity. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 33 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 12 | 36% |
| Student > Ph. D. Student | 7 | 21% |
| Student > Master | 6 | 18% |
| Professor | 2 | 6% |
| Other | 2 | 6% |
| Other | 0 | 0% |
| Unknown | 4 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 9 | 27% |
| Biochemistry, Genetics and Molecular Biology | 7 | 21% |
| Medicine and Dentistry | 5 | 15% |
| Agricultural and Biological Sciences | 4 | 12% |
| Nursing and Health Professions | 1 | 3% |
| Other | 3 | 9% |
| Unknown | 4 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 January 2024.
All research outputs
#8,270,860
of 25,394,764 outputs
Outputs from Cell Reports
#10,230
of 12,973 outputs
Outputs of similar age
#137,230
of 416,622 outputs
Outputs of similar age from Cell Reports
#219
of 266 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 12,973 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 30.3. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 416,622 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 266 others from the same source and published within six weeks on either side of this one. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.