| Title |
Drug transport to brain with targeted nanoparticles
|
|---|---|
| Published in |
Neurotherapeutics, January 2005
|
| DOI | 10.1602/neurorx.2.1.108 |
| Pubmed ID | |
| Authors |
Jean-Christophe Olivier |
| Abstract |
Nanoparticle drug carriers consist of solid biodegradable particles in size ranging from 10 to 1000 nm (50-300 nm generally). They cannot freely diffuse through the blood-brain barrier (BBB) and require receptor-mediated transport through brain capillary endothelium to deliver their content into the brain parenchyma. Polysorbate 80-coated polybutylcyanoacrylate nanoparticles can deliver drugs to the brain by a still debated mechanism. Despite interesting results these nanoparticles have limitations, discussed in this review, that may preclude, or at least limit, their potential clinical applications. Long-circulating nanoparticles made of methoxypoly(ethylene glycol)- polylactide or poly(lactide-co-glycolide) (mPEG-PLA/PLGA) have a good safety profiles and provide drug-sustained release. The availability of functionalized PEG-PLA permits to prepare target-specific nanoparticles by conjugation of cell surface ligand. Using peptidomimetic antibodies to BBB transcytosis receptor, brain-targeted pegylated immunonanoparticles can now be synthesized that should make possible the delivery of entrapped actives into the brain parenchyma without inducing BBB permeability alteration. This review presents their general properties (structure, loading capacity, pharmacokinetics) and currently available methods for immunonanoparticle preparation. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 452 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 6 | 1% |
| United Kingdom | 3 | <1% |
| Germany | 2 | <1% |
| United States | 2 | <1% |
| Russia | 2 | <1% |
| Italy | 1 | <1% |
| France | 1 | <1% |
| Netherlands | 1 | <1% |
| Switzerland | 1 | <1% |
| Other | 3 | <1% |
| Unknown | 430 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 120 | 27% |
| Student > Master | 66 | 15% |
| Researcher | 65 | 14% |
| Student > Bachelor | 53 | 12% |
| Student > Postgraduate | 28 | 6% |
| Other | 76 | 17% |
| Unknown | 44 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 82 | 18% |
| Pharmacology, Toxicology and Pharmaceutical Science | 63 | 14% |
| Medicine and Dentistry | 58 | 13% |
| Chemistry | 56 | 12% |
| Biochemistry, Genetics and Molecular Biology | 35 | 8% |
| Other | 89 | 20% |
| Unknown | 69 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 31. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 July 2021.
All research outputs
#1,263,031
of 25,371,288 outputs
Outputs from Neurotherapeutics
#90
of 1,308 outputs
Outputs of similar age
#2,528
of 151,249 outputs
Outputs of similar age from Neurotherapeutics
#2
of 14 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,308 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.2. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 151,249 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.