| Title |
Glial Activation and Segmental Upregulation of Interleukin-1β (IL-1β) in the Rat Spinal Cord after Surgical Incision
|
|---|---|
| Published in |
Neurochemical Research, May 2006
|
| DOI | 10.1007/s11064-005-9032-4 |
| Pubmed ID | |
| Authors |
Di Fu, Qulian Guo, Yuhang Ai, Hongwei Cai, Jianqin Yan, Ruping Dai |
| Abstract |
The present study investigated the expression patterns of glial cells and interleukin-1beta (IL-1beta) in the rat spinal cord after a surgical incision, which is closely related with clinical postoperative pain. Microglia and astrocytes became activated in the spinal cord following incision. Real-time polymerase chain reaction (PCR) and immunohistochemisty showed that IL-1beta mRNA and protein level in the spinal cord was transiently upregulated after surgical incision. The increased IL-1beta-immunoreactivity (IR) was mainly localized in neurons but not the activated microglia or astrocytes. Although obvious increase in IL-1beta-IR could be observed in the lumbar segments of the spinal cord ipsilateral to a hind paw incision, significant upregulation of IL-1beta was not detected in the lumbar segments following thoracic incision. The present study indicated that surgical incision could induce glial activation and segmental upregulation of IL-1beta in the spinal cord. The activated glial cells and upregulated IL-1beta, in turn, may be involved in the incision-induced pain hypersensitivity. |
Mendeley readers
The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 9% |
| Unknown | 10 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 4 | 36% |
| Student > Ph. D. Student | 2 | 18% |
| Professor | 2 | 18% |
| Other | 1 | 9% |
| Student > Bachelor | 1 | 9% |
| Other | 1 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 5 | 45% |
| Agricultural and Biological Sciences | 3 | 27% |
| Veterinary Science and Veterinary Medicine | 1 | 9% |
| Social Sciences | 1 | 9% |
| Neuroscience | 1 | 9% |
| Other | 0 | 0% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 May 2006.
All research outputs
#15,271,909
of 22,710,079 outputs
Outputs from Neurochemical Research
#1,280
of 2,088 outputs
Outputs of similar age
#57,765
of 65,908 outputs
Outputs of similar age from Neurochemical Research
#8
of 10 outputs
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