| Title |
The role of HER2, EGFR, and other receptor tyrosine kinases in breast cancer
|
|---|---|
| Published in |
Cancer and Metastasis Reviews, December 2016
|
| DOI | 10.1007/s10555-016-9649-6 |
| Pubmed ID | |
| Authors |
Jennifer L. Hsu, Mien-Chie Hung |
| Abstract |
Breast cancer affects approximately 1 in 8 women, and it is estimated that over 246,660 women in the USA will be diagnosed with breast cancer in 2016. Breast cancer mortality has decline over the last two decades due to early detection and improved treatment. Over the last few years, there is mounting evidence to demonstrate the prominent role of receptor tyrosine kinases (RTKs) in tumor initiation and progression, and targeted therapies against the RTKs have been developed, evaluated in clinical trials, and approved for many cancer types, including breast cancer. However, not all breast cancers are the same as evidenced by the multiple subtypes of the disease, with some more aggressive than others, showing differential treatment response to different types of drugs. Moreover, in addition to canonical signaling from the cell surface, many RTKs can be trafficked to various subcellular compartments, e.g., the multivesicular body and nucleus, where they carry out critical cellular functions, such as cell proliferation, DNA replication and repair, and therapeutic resistance. In this review, we provide a brief summary on the role of a selected number of RTKs in breast cancer and describe some mechanisms of resistance to targeted therapies. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 402 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 402 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 65 | 16% |
| Student > Ph. D. Student | 49 | 12% |
| Student > Master | 46 | 11% |
| Researcher | 25 | 6% |
| Student > Doctoral Student | 18 | 4% |
| Other | 54 | 13% |
| Unknown | 145 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 92 | 23% |
| Medicine and Dentistry | 38 | 9% |
| Agricultural and Biological Sciences | 27 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 26 | 6% |
| Chemistry | 24 | 6% |
| Other | 41 | 10% |
| Unknown | 154 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 September 2022.
All research outputs
#3,582,190
of 25,483,400 outputs
Outputs from Cancer and Metastasis Reviews
#86
of 876 outputs
Outputs of similar age
#65,460
of 416,653 outputs
Outputs of similar age from Cancer and Metastasis Reviews
#2
of 9 outputs
Altmetric has tracked 25,483,400 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 876 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 416,653 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 7 of them.