Title |
Iron deficiency or anemia of inflammation?
|
---|---|
Published in |
Wiener Medizinische Wochenschrift, August 2016
|
DOI | 10.1007/s10354-016-0505-7 |
Pubmed ID | |
Authors |
Manfred Nairz, Igor Theurl, Dominik Wolf, Günter Weiss |
Abstract |
Iron deficiency and immune activation are the two most frequent causes of anemia, both of which are based on disturbances of iron homeostasis. Iron deficiency anemia results from a reduction of the body's iron content due to blood loss, inadequate dietary iron intake, its malabsorption, or increased iron demand. Immune activation drives a diversion of iron fluxes from the erythropoietic bone marrow, where hemoglobinization takes place, to storage sites, particularly the mononuclear phagocytes system in liver and spleen. This results in iron-limited erythropoiesis and anemia. This review summarizes current diagnostic and pathophysiological concepts of iron deficiency anemia and anemia of inflammation, as well as combined conditions, and provides a brief outlook on novel therapeutic options. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 79 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 12 | 15% |
Student > Ph. D. Student | 10 | 13% |
Student > Master | 7 | 9% |
Researcher | 6 | 8% |
Student > Postgraduate | 5 | 6% |
Other | 13 | 16% |
Unknown | 26 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 23 | 29% |
Nursing and Health Professions | 8 | 10% |
Biochemistry, Genetics and Molecular Biology | 7 | 9% |
Agricultural and Biological Sciences | 4 | 5% |
Veterinary Science and Veterinary Medicine | 3 | 4% |
Other | 4 | 5% |
Unknown | 30 | 38% |