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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Heritability of the shape of subcortical brain structures in the general population
|
|---|---|
| Published in |
Nature Communications, December 2016
|
| DOI | 10.1038/ncomms13738 |
| Pubmed ID | |
| Authors |
Gennady V. Roshchupkin, Boris A. Gutman, Meike W. Vernooij, Neda Jahanshad, Nicholas G. Martin, Albert Hofman, Katie L. McMahon, Sven J. van der Lee, Cornelia M. van Duijn, Greig I. de Zubicaray, André G. Uitterlinden, Margaret J. Wright, Wiro J. Niessen, Paul M. Thompson, M. Arfan Ikram, Hieab H. H. Adams |
| Abstract |
The volumes of subcortical brain structures are highly heritable, but genetic underpinnings of their shape remain relatively obscure. Here we determine the relative contribution of genetic factors to individual variation in the shape of seven bilateral subcortical structures: the nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen and thalamus. In 3,686 unrelated individuals aged between 45 and 98 years, brain magnetic resonance imaging and genotyping was performed. The maximal heritability of shape varies from 32.7 to 53.3% across the subcortical structures. Genetic contributions to shape extend beyond influences on intracranial volume and the gross volume of the respective structure. The regional variance in heritability was related to the reliability of the measurements, but could not be accounted for by technical factors only. These findings could be replicated in an independent sample of 1,040 twins. Differences in genetic contributions within a single region reveal the value of refined brain maps to appreciate the genetic complexity of brain structures. |
X Demographics
The data shown below were collected from the profiles of 23 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 9% |
| United Kingdom | 2 | 9% |
| Australia | 2 | 9% |
| Mexico | 2 | 9% |
| Japan | 1 | 4% |
| Ireland | 1 | 4% |
| Canada | 1 | 4% |
| France | 1 | 4% |
| Netherlands | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 10 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 18 | 78% |
| Scientists | 4 | 17% |
| Science communicators (journalists, bloggers, editors) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Unknown | 84 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 29% |
| Researcher | 14 | 16% |
| Student > Master | 8 | 9% |
| Student > Postgraduate | 7 | 8% |
| Student > Doctoral Student | 6 | 7% |
| Other | 12 | 14% |
| Unknown | 13 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 16 | 19% |
| Psychology | 12 | 14% |
| Medicine and Dentistry | 9 | 11% |
| Biochemistry, Genetics and Molecular Biology | 8 | 9% |
| Agricultural and Biological Sciences | 7 | 8% |
| Other | 11 | 13% |
| Unknown | 22 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 September 2018.
All research outputs
#3,081,856
of 25,711,194 outputs
Outputs from Nature Communications
#32,488
of 58,175 outputs
Outputs of similar age
#56,722
of 423,346 outputs
Outputs of similar age from Nature Communications
#472
of 866 outputs
Altmetric has tracked 25,711,194 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 58,175 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.4. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 423,346 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 866 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.