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Potent Inhibition of Hendra Virus Infection via RNA Interference and Poly I:C Immune Activation

Overview of attention for article published in PLOS ONE, May 2013
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  • Above-average Attention Score compared to outputs of the same age and source (51st percentile)

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Title
Potent Inhibition of Hendra Virus Infection via RNA Interference and Poly I:C Immune Activation
Published in
PLOS ONE, May 2013
DOI 10.1371/journal.pone.0064360
Pubmed ID
Authors

Jana L. McCaskill, Glenn A. Marsh, Paul Monaghan, Lin-Fa Wang, Timothy Doran, Nigel A. J. McMillan

Abstract

Hendra virus (HeV) is a highly pathogenic zoonotic paramyxovirus that causes fatal disease in a wide range of species, including humans. HeV was first described in Australia in 1994, and has continued to re-emerge with increasing frequency. HeV is of significant concern to human health due to its high mortality rate, increasing emergence, absence of vaccines and limited post exposure therapies. Here we investigate the use of RNA interference (RNAi) based therapeutics targeting HeV in conjunction with the TLR3 agonist Poly I:C and show that they are potent inhibitors of HeV infection in vitro. We found that short interfering RNAs (siRNAs) targeting the abundantly expressed N, P and M genes of HeV caused over 95% reduction of HeV virus titre, protein and mRNA. Furthermore, we found that the combination of HeV targeting siRNA and Poly I:C had an additive effect in suppressing HeV infection. Our results demonstrate for the first time that RNAi and type I interferon stimulation are effective inhibitors of HeV replication in vitro and may provide an effective therapy for this highly lethal, zoonotic pathogen.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 25%
Student > Ph. D. Student 5 21%
Student > Master 4 17%
Student > Bachelor 2 8%
Lecturer 1 4%
Other 2 8%
Unknown 4 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 25%
Medicine and Dentistry 5 21%
Biochemistry, Genetics and Molecular Biology 4 17%
Veterinary Science and Veterinary Medicine 2 8%
Environmental Science 1 4%
Other 2 8%
Unknown 4 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 May 2013.
All research outputs
#12,683,706
of 22,710,079 outputs
Outputs from PLOS ONE
#98,209
of 193,906 outputs
Outputs of similar age
#96,173
of 194,054 outputs
Outputs of similar age from PLOS ONE
#2,367
of 4,999 outputs
Altmetric has tracked 22,710,079 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 193,906 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 194,054 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 4,999 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.