| Title |
Early postoperative cognitive dysfunction is associated with higher cortisol levels in aged patients following hip fracture surgery
|
|---|---|
| Published in |
Journal of Anesthesia, May 2013
|
| DOI | 10.1007/s00540-013-1633-5 |
| Pubmed ID | |
| Authors |
Mu-Huo Ji, Jin-Chun Shen, Rong Gao, Xiao-Yu Liu, Hong-Mei Yuan, Lin Dong, Jing Wu, Shan-Wu Feng, Wei-Yan Li, Jian-Jun Yang |
| Abstract |
This study aimed to evaluate the relationship between plasma cortisol levels and the occurrence of postoperative cognitive dysfunction (POCD) in aged patients following hip fracture surgery. A total of 175 patients, aged 65 years or older, who were scheduled for hip fracture surgery with spinal anesthesia were enrolled. Perioperative plasma levels of cortisol and neurocognitive tests were determined at 1 day preoperatively and 7 days postoperatively. Seventy-seven patients completed both blood sample collections and neurocognitive tests. POCD occurred in 29.9 % of patients at 7 days postoperatively. POCD patients presented significantly higher cortisol levels compared with non-POCD patients (P < 0.05). Furthermore, plasma cortisol levels were negatively correlated with mini-mental state examination (MMSE) scores at 7 days postoperatively (P < 0.0001). A specificity of 93 % and a sensitivity of 35 % were identified for the plasma cortisol measurement to discriminate POCD patients from non-POCD patients. The results suggest higher plasma cortisol levels are associated with POCD in aged patients following hip fracture surgery with spinal anesthesia. |
Mendeley readers
The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 3% |
| Germany | 1 | 3% |
| Unknown | 37 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Postgraduate | 9 | 23% |
| Student > Bachelor | 6 | 15% |
| Student > Ph. D. Student | 5 | 13% |
| Student > Doctoral Student | 4 | 10% |
| Researcher | 3 | 8% |
| Other | 8 | 21% |
| Unknown | 4 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 19 | 49% |
| Neuroscience | 4 | 10% |
| Biochemistry, Genetics and Molecular Biology | 3 | 8% |
| Psychology | 3 | 8% |
| Nursing and Health Professions | 2 | 5% |
| Other | 3 | 8% |
| Unknown | 5 | 13% |