| Title |
Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile
|
|---|---|
| Published in |
BMC Medicine, May 2013
|
| DOI | 10.1186/1741-7015-11-129 |
| Pubmed ID | |
| Authors |
Brenda WJH Penninx, Yuri Milaneschi, Femke Lamers, Nicole Vogelzangs |
| Abstract |
Depression is the most common psychiatric disorder worldwide. The burden of disease for depression goes beyond functioning and quality of life and extends to somatic health. Depression has been shown to subsequently increase the risk of, for example, cardiovascular, stroke, diabetes and obesity morbidity. These somatic consequences could partly be due to metabolic, immuno-inflammatory, autonomic and hypothalamic-pituitary-adrenal (HPA)-axis dysregulations which have been suggested to be more often present among depressed patients. Evidence linking depression to metabolic syndrome abnormalities indicates that depression is especially associated with its obesity-related components (for example, abdominal obesity and dyslipidemia). In addition, systemic inflammation and hyperactivity of the HPA-axis have been consistently observed among depressed patients. Slightly less consistent observations are for autonomic dysregulation among depressed patients. The heterogeneity of the depression concept seems to play a differentiating role: metabolic syndrome and inflammation up-regulations appear more specific to the atypical depression subtype, whereas hypercortisolemia appears more specific for melancholic depression. This review finishes with potential treatment implications for the downward spiral in which different depressive symptom profiles and biological dysregulations may impact on each other and interact with somatic health decline. |
X Demographics
The data shown below were collected from the profiles of 22 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | 18% |
| United States | 3 | 14% |
| Greece | 1 | 5% |
| Netherlands | 1 | 5% |
| Venezuela, Bolivarian Republic of | 1 | 5% |
| Unknown | 12 | 55% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 15 | 68% |
| Scientists | 5 | 23% |
| Practitioners (doctors, other healthcare professionals) | 2 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 881 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | <1% |
| Spain | 2 | <1% |
| India | 2 | <1% |
| Switzerland | 1 | <1% |
| Netherlands | 1 | <1% |
| Portugal | 1 | <1% |
| Brazil | 1 | <1% |
| United Kingdom | 1 | <1% |
| Unknown | 868 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 156 | 18% |
| Student > Master | 124 | 14% |
| Student > Ph. D. Student | 122 | 14% |
| Researcher | 64 | 7% |
| Student > Postgraduate | 47 | 5% |
| Other | 151 | 17% |
| Unknown | 217 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 209 | 24% |
| Psychology | 124 | 14% |
| Agricultural and Biological Sciences | 58 | 7% |
| Neuroscience | 50 | 6% |
| Nursing and Health Professions | 49 | 6% |
| Other | 130 | 15% |
| Unknown | 261 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 27. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 April 2022.
All research outputs
#1,440,804
of 25,837,817 outputs
Outputs from BMC Medicine
#1,011
of 4,075 outputs
Outputs of similar age
#11,397
of 208,573 outputs
Outputs of similar age from BMC Medicine
#23
of 69 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,075 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 45.8. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 208,573 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 69 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.