Title |
A large-scale genome-wide association and meta-analysis identified four novel susceptibility loci for leprosy
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Published in |
Nature Communications, December 2016
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DOI | 10.1038/ncomms13760 |
Pubmed ID | |
Authors |
Zhenzhen Wang, Yonghu Sun, Xi’an Fu, Gongqi Yu, Chuan Wang, Fangfang Bao, Zhenhua Yue, Jianke Li, Lele Sun, Astrid Irwanto, Yongxiang Yu, Mingfei Chen, Zihao Mi, Honglei Wang, Pengcheng Huai, Yi Li, Tiantian Du, Wenjun Yu, Yang Xia, Hailu Xiao, Jiabao You, Jinghui Li, Qing Yang, Na Wang, Panpan Shang, Guiye Niu, Xiaojun Chi, Xiuhuan Wang, Jing Cao, Xiujun Cheng, Hong Liu, Jianjun Liu, Furen Zhang |
Abstract |
Leprosy, a chronic infectious disease, results from the uncultivable pathogen Mycobacterium leprae (M. leprae), and usually progresses to peripheral neuropathy and permanent progressive deformity if not treated. Previously published genetic studies have identified 18 gene/loci significantly associated with leprosy at the genome-wide significant level. However as a complex disease, only a small proportion of leprosy risk could be explained by those gene/loci. To further identify more susceptibility gene/loci, we hereby performed a three-stage GWAS comprising 8,156 leprosy patients and 15,610 controls of Chinese ancestry. Four novel loci were identified including rs6807915 on 3p25.2 (P=1.94 × 10(-8), OR=0.89), rs4720118 on 7p14.3 (P=3.85 × 10(-10), OR=1.16), rs55894533 on 8p23.1 (P=5.07 × 10(-11), OR=1.15) and rs10100465 on 8q24.11 (P=2.85 × 10(-11), OR=0.85). Altogether, these findings have provided new insight and significantly expanded our understanding of the genetic basis of leprosy. |
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