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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A large-scale genome-wide association and meta-analysis identified four novel susceptibility loci for leprosy
|
|---|---|
| Published in |
Nature Communications, December 2016
|
| DOI | 10.1038/ncomms13760 |
| Pubmed ID | |
| Authors |
Zhenzhen Wang, Yonghu Sun, Xi’an Fu, Gongqi Yu, Chuan Wang, Fangfang Bao, Zhenhua Yue, Jianke Li, Lele Sun, Astrid Irwanto, Yongxiang Yu, Mingfei Chen, Zihao Mi, Honglei Wang, Pengcheng Huai, Yi Li, Tiantian Du, Wenjun Yu, Yang Xia, Hailu Xiao, Jiabao You, Jinghui Li, Qing Yang, Na Wang, Panpan Shang, Guiye Niu, Xiaojun Chi, Xiuhuan Wang, Jing Cao, Xiujun Cheng, Hong Liu, Jianjun Liu, Furen Zhang |
| Abstract |
Leprosy, a chronic infectious disease, results from the uncultivable pathogen Mycobacterium leprae (M. leprae), and usually progresses to peripheral neuropathy and permanent progressive deformity if not treated. Previously published genetic studies have identified 18 gene/loci significantly associated with leprosy at the genome-wide significant level. However as a complex disease, only a small proportion of leprosy risk could be explained by those gene/loci. To further identify more susceptibility gene/loci, we hereby performed a three-stage GWAS comprising 8,156 leprosy patients and 15,610 controls of Chinese ancestry. Four novel loci were identified including rs6807915 on 3p25.2 (P=1.94 × 10(-8), OR=0.89), rs4720118 on 7p14.3 (P=3.85 × 10(-10), OR=1.16), rs55894533 on 8p23.1 (P=5.07 × 10(-11), OR=1.15) and rs10100465 on 8q24.11 (P=2.85 × 10(-11), OR=0.85). Altogether, these findings have provided new insight and significantly expanded our understanding of the genetic basis of leprosy. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 22% |
| Switzerland | 2 | 22% |
| United States | 1 | 11% |
| Spain | 1 | 11% |
| Netherlands | 1 | 11% |
| Unknown | 2 | 22% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 67% |
| Scientists | 2 | 22% |
| Practitioners (doctors, other healthcare professionals) | 1 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 63 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 10 | 16% |
| Student > Ph. D. Student | 9 | 14% |
| Student > Bachelor | 8 | 13% |
| Researcher | 8 | 13% |
| Student > Doctoral Student | 7 | 11% |
| Other | 10 | 16% |
| Unknown | 11 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 15 | 24% |
| Agricultural and Biological Sciences | 12 | 19% |
| Medicine and Dentistry | 7 | 11% |
| Immunology and Microbiology | 5 | 8% |
| Environmental Science | 3 | 5% |
| Other | 8 | 13% |
| Unknown | 13 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 September 2018.
All research outputs
#6,539,430
of 24,226,848 outputs
Outputs from Nature Communications
#37,231
of 51,495 outputs
Outputs of similar age
#114,872
of 429,328 outputs
Outputs of similar age from Nature Communications
#607
of 869 outputs
Altmetric has tracked 24,226,848 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 51,495 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 56.3. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 429,328 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 869 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.