You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Constitutively active Foxo3 in oocytes preserves ovarian reserve in mice
|
|---|---|
| Published in |
Nature Communications, May 2013
|
| DOI | 10.1038/ncomms2861 |
| Pubmed ID | |
| Authors |
Emanuele Pelosi, Shakib Omari, Marc Michel, Jun Ding, Tomokazu Amano, Antonino Forabosco, David Schlessinger, Chris Ottolenghi |
| Abstract |
During female reproductive life, ovarian follicle reserve is reduced by maturation and atresia until menopause ensues. Foxo3 is required to maintain the ovarian reserve in mice. Here we show that overexpression of constitutively active FOXO3 can increase ovarian reproductive capacity in mice. We find increased follicle numbers and decreased gonadotropin levels in aging FOXO3-transgenic mice compared with wild-type littermates, suggesting maintenance of a greater ovarian reserve. Based on cumulative progeny in aging animals, we find 31-49% increased fertility in transgenic females. The gene expression profile of Foxo3-/- knockout ovaries appears older than that of wild-type littermates, and the transgene induces a younger-looking profile, restoring much of the wild-type transcriptome. This is the first gain-of-function model of augmented reproductive reserve in mice, thus emphasizing the role of Foxo3 as a guardian of the ovarian follicle pool in mammals and a potential determinant of the onset of menopause. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 91 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 2 | 2% |
| Unknown | 89 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 19 | 21% |
| Student > Ph. D. Student | 16 | 18% |
| Student > Bachelor | 11 | 12% |
| Student > Doctoral Student | 7 | 8% |
| Student > Master | 7 | 8% |
| Other | 15 | 16% |
| Unknown | 16 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 29 | 32% |
| Agricultural and Biological Sciences | 24 | 26% |
| Medicine and Dentistry | 8 | 9% |
| Veterinary Science and Veterinary Medicine | 3 | 3% |
| Nursing and Health Professions | 2 | 2% |
| Other | 6 | 7% |
| Unknown | 19 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 September 2017.
All research outputs
#8,333,719
of 25,559,053 outputs
Outputs from Nature Communications
#44,340
of 57,618 outputs
Outputs of similar age
#68,589
of 206,370 outputs
Outputs of similar age from Nature Communications
#245
of 351 outputs
Altmetric has tracked 25,559,053 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 57,618 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.5. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 206,370 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 351 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.